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A kind of glioma prognostic marker cpvl and its application

A prognostic marker and glioma technology, applied in biochemical equipment and methods, microbiological measurement/testing, DNA/RNA fragments, etc., can solve the problem that the pathogenesis of glioma is not completely clear, and glioma has not been significantly improved To achieve the effect of inhibiting tumorigenic ability and inhibiting proliferation

Active Publication Date: 2022-04-08
THE FIRST AFFILIATED HOSPITAL OF WANNAN MEDICAL COLLEGE YIJISHAN HOSPITAL OF WANNAN MEDICAL COLLEGE
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Problems solved by technology

The current traditional therapies such as surgical resection, radiotherapy, and chemotherapy have not significantly improved the prognosis of patients with glioma, which has always been a major problem in the treatment of malignant tumors of the central nervous system. The fundamental reason is that the pathogenesis of glioma has not yet been fully aware

Method used

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  • A kind of glioma prognostic marker cpvl and its application
  • A kind of glioma prognostic marker cpvl and its application
  • A kind of glioma prognostic marker cpvl and its application

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Embodiment Construction

[0045] The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, but not all of the embodiments.

[0046] refer to Figure 1-15 , a glioma prognostic marker CPVLmRNA, its sequence number is shown in Table 1.

[0047] Table 1:

[0048]

[0049]

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Abstract

The present invention relates to the field of biotechnology, and in particular to a glioma prognostic marker CPVL and its application. The following scheme is proposed, a glioma prognostic marker CPVLmRNA, which detects the expression level of the marker CPVLmRNA in glioma tissue The application of reagents in the preparation of glioma prognostic preparations, a glioma prognostic kit, capable of detecting the content of marker CPVLmRNA in glioma tissue, including PCR primers for detecting the content of marker CPVLmRNA, a gel Application of tumor prognostic marker CPVLmRNA. The present invention can effectively verify that CPVL knockdown can promote glioma cell apoptosis, inhibit glioma cell proliferation and tumorigenicity, regulate glioma cell cycle, CPVL knockdown induces glioma cell apoptosis, and elucidates the The pathogenesis of glioma has important theoretical and practical significance, and the oncogene CPVL plays an important role in the occurrence and development of glioma, thus providing a potential therapeutic target for the treatment of glioma.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a glioma prognostic marker CPVL and its application. Background technique [0002] Glioma is the most common intracranial malignant tumor clinically. Due to the influence of various physical, chemical, genetic and other factors, the incidence of glioma often ranks first in intracranial tumors, accounting for about 50% of brain tumors. Glioma has the characteristics of insidious onset, fast growth, easy invasion and metastasis, high fatality rate, and short average survival period. It has become a type of disease that causes great harm to human life and health. The current traditional therapies such as surgical resection, radiotherapy, and chemotherapy have not significantly improved the prognosis of patients with glioma, which has always been a major problem in the treatment of malignant tumors of the central nervous system. The fundamental reason is that the pathogenesis of glioma ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6886C12N15/113
Inventor 吕坤杨辉李雪琴
Owner THE FIRST AFFILIATED HOSPITAL OF WANNAN MEDICAL COLLEGE YIJISHAN HOSPITAL OF WANNAN MEDICAL COLLEGE
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