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Method for identifying adefovir dipivoxil tablets

Adefovir dipivoxil tablet, standard technology, applied in the field of drug analysis, can solve the problem of high degree of counterfeiting, and achieve the effect of high sensitivity

Inactive Publication Date: 2019-05-31
SHANDONG INST FOR FOOD & DRUG CONTROL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the high degree of counterfeiting of inferior drugs on the market, ordinary technical means cannot be identified

Method used

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  • Method for identifying adefovir dipivoxil tablets
  • Method for identifying adefovir dipivoxil tablets
  • Method for identifying adefovir dipivoxil tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1.1 Materials: Genuine adefovir dipivoxil tablets (manufacturer: Chenxin Pharmaceutical Co., Ltd.; batch number: 180115543, 180115541; specification: 10mg), adefovir dipivoxil raw materials, main excipients, all produced by Chenxin Pharmaceutical Co., Ltd. Limited offer.

[0027] Instrument: i-Raman (model: BW415, manufacturer: Bida Tech Co., Ltd., USA)

[0028] 1.2 Acquisition parameters: laser wavelength: 785nm; integration time: 7000ms; laser power: 50; average times: 6 times; time multiplier: 1.

[0029] 1.3 Sample collection, processing and analysis: Randomly take 6 genuine adefovir dipivoxil tablets, remove the coating, collect the Raman spectrum of each tablet under the above collection conditions, select 3~6 spectra and upload them to the RACOFIC system, and take the average The spectrum is used as a standard spectrum for identification. Other samples: directly measure the sample to be tested without coating, measure the coated tablet after removing the coatin...

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Abstract

The invention discloses a method for identifying adefovir dipivoxil tablets. The method comprises the following steps of: (1) performing Raman spectrometer scanning for a standard adefovir dipivoxil tablet, setting the number of scanning times for 1-10, and saving the mean values of spectrums under different scanning times; (2) obtaining a spectrum chart, and selecting a standard feature peak of amain material and a standard feature peak of an auxiliary material; (3) performing Raman spectrometer scanning of a sample to be tested to obtain a spectrum chart, and selecting a feature peak near the main material and a feature peak near the auxiliary material for comparison with the standard feature peaks; and (4) performing determination. The method is rapid, accurate and high in sensitivity,and provides an idea for the authenticity identification of adefovir dipivoxil tablets with no need for comparison of all the feature peaks of the main material and the auxiliary material and with only comparison of necessary feature peaks, and through calculation of a formula, the method for identifying adefovir dipivoxil tablets can identify that the adefovir dipivoxil tablets are real drugs, false drugs or drugs of inferior quality.

Description

technical field [0001] The invention belongs to the technical field of drug analysis, and in particular relates to a method for identifying adefovir dipivoxil tablets. Background technique [0002] my country is a high-incidence area of ​​hepatitis B, which can be called a "big hepatitis country". According to the statistical data of the Ministry of Health in 2002, the prevalence rate of hepatitis B in my country is 2.77 / 10,000, more than 40 times that of the United States, and the annual incidence rate is 950,000. Among legal infectious diseases, its incidence is second only to infectious diarrhea and influenza and ranks third. Epidemiological surveys show that at least 800 million people in my country have been infected with hepatitis B, and the carrier rate of hepatitis B surface antigen in the Chinese population is as high as 10.34%, that is to say, about 130 million people are carriers of hepatitis B virus, accounting for almost all Half of the world's total, a quarter...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65
Inventor 张中湖苏美
Owner SHANDONG INST FOR FOOD & DRUG CONTROL