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A kind of benzamide small molecule inhibitor and its application in inhibiting ornithine decarboxylase

A technology of small molecule inhibitors and ornithine decarboxylase, which is applied to medical preparations containing active ingredients, organic active ingredients, pharmaceutical formulations, etc., can solve problems such as large toxic side effects, high concentration of action, and weak binding ability

Active Publication Date: 2021-05-14
HUBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its binding ability to ODC is weak, and its concentration is very high, and because it is a suicide inhibitor that forms a covalent bond with ODC, its toxic and side effects are very large

Method used

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  • A kind of benzamide small molecule inhibitor and its application in inhibiting ornithine decarboxylase
  • A kind of benzamide small molecule inhibitor and its application in inhibiting ornithine decarboxylase
  • A kind of benzamide small molecule inhibitor and its application in inhibiting ornithine decarboxylase

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Embodiment 1

[0037] The benzamide small molecule inhibitor involved is: 2,3,4,5,6-pentafluoro-N-(3-fluoroalkenyl)benzamide, the structural formula of which is shown in the figure.

[0038]

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Abstract

The present invention provides a kind of benzamide small molecule inhibitor, and this small molecule inhibitor is 2,3,4,5,6-pentafluoro-N-(3-fluoroalkenyl) benzamide, and structural formula is as follows: The present invention The application of the benzamide small-molecule inhibitor in inhibiting ornithine decarboxylase (ODC), in the preparation of a drug for treating tumors, and in the preparation of a drug for treating pathogenic microorganism infection has achieved remarkable effects.

Description

technical field [0001] The invention relates to a small-molecule inhibitor of ornithine decarboxylase (Ornithine decarboxylase; ODC) and its application, in particular to a small-molecule inhibitor of human ornithine decarboxylase and its application in inhibiting and killing tumor cells. Background technique [0002] Protein is one of the main components of organisms and the main substance to complete various life activities. Among various proteins, proteases are crucial to life activities, and almost all biochemical reactions in organisms are catalyzed by proteases. The activity of various proteases in organisms has a strict regulation mechanism. Once there is a problem with the regulation mechanism, the activity of proteases is too high, too low or completely inactivated, which will cause various diseases. Therefore, it has very important theoretical and practical significance to regulate the activity of protease by drugs to restore and maintain it at a normal level. St...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/167A61P35/00A61P31/00
Inventor 刘森苏正定黄永棋占景琼柴晓颖潘静成细瑶
Owner HUBEI UNIV OF TECH
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