Sarcandra injection, preparation method of sarcandra injection, and intravenous administration of sarcandra injection

A technology for injections and sarcomas, applied in the direction of antineoplastic drugs, antipyretics, anti-inflammatory agents, etc., can solve problems such as inconvenient use, muscle necrosis, pain, etc., to avoid inconvenient use and high bioavailability , to avoid the effect of degradation

Inactive Publication Date: 2019-07-02
李芳凯
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Since the existing route of administration of Zhongjiefeng Injection is intramuscular injection, it is inconvenient to use clinically, the administration site of the patient is painful, and it is easy to cause adverse reactions such as congestion and even muscle necrosis.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039]Take 1000g of sarcophagus, add 6 times the weight of sarcophagus, boil and decoct 2 times, each time for 2 hours, filter with filter paper, combine the two filtrates, and concentrate each ml of liquid medicine containing 1g of crude drug; add to the concentrated solution Add 0.05% of the weight of the concentrated liquid clarifier B, heat to 70-90 ° C, let stand for 2 hours, then add 0.025% of the weight of the concentrated liquid clarifier A, let stand for 4 hours, centrifuge, and pour the supernatant and concentrated to 3g of crude drug per ml of medicinal liquid; add ethanol under slow stirring, add ethanol to make the alcohol content 75%, refrigerate at 4-8°C for 48 hours, filter with filter paper, recover ethanol from the filtrate, and concentrate to per ml The medicinal solution contains 3g of crude drug, add ethanol to make the alcohol content 85%, refrigerate at 4-8°C for 48 hours, filter with filter paper, recover ethanol from the filtrate, concentrate the filtra...

Embodiment 2

[0041] Get 2000g of sarcophagus, add 8 times the weight of sarcophagus, boil and decoct 2 times, each time for 3 hours, filter with filter paper, combine the two filtrates, and concentrate each ml of medicinal solution containing 1.5g of crude drug; add to the concentrated solution Add 0.04% of the weight of the concentrated solution to the clarifier B, heat to 70-90 ° C, let it stand for 2 hours, then add 0.02% of the weight of the concentrated solution A clarifier, after standing for 4 hours, centrifuge, and the supernatant Pour out and concentrate to 4g of crude drug per ml of liquid medicine; add ethanol under slow stirring, add ethanol to make the alcohol content to 70%, refrigerate at 4-8°C for 48 hours, filter through filter paper, recover ethanol from the filtrate, and concentrate to every The medicinal solution in ml contains 4g of crude drug, add ethanol to make the alcohol content 80%, refrigerate at 4-8°C for 48 hours, filter with filter paper, recover ethanol from ...

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PUM

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Abstract

The invention relates to a sarcandra injection, a preparation method of the sarcandra injection as well as intravenous administration of the sarcandra injection, and belongs to the field of traditional Chinese medicine preparations. The preparation method of the sarcandra injection utilizes 1-1000 parts by weight of raw materials, and comprises the following steps: boiling the raw materials with water, carrying out concentrating, adding a clarifying agent, carrying out alcohol precipitation, carrying out water precipitation, carrying out ultra-filtration so as to obtain active ingredients of sarcandra, carrying out sub-packaging, and carrying out sterilization so as to obtain the sarcandra injection; and each milliliter of the prepared sarcandra injection contain no less than 30 microgramsof fumaric acid. The sarcandra injection prepared by the preparation method has the functions of resisting bacteria, diminishing inflammation, expelling pathogenic wind, dredging collateral, activating the circulation of the blood and eliminating stagnation; and thus, the sarcandra injection can be used for treating diseases such as pneumonia, appendicitis, cellulitis, rheumatism, arthralgia, fall injury and the like. Moreover, the sarcandra injection can also be used as an adjuvant therapy for cancer. The sarcandra injection disclosed by the invention can be intravenously administered, so that, the sarcandra injection is high in bioavailability, easy to use, few in adverse reactions and capable of avoiding inconvenience in clinical use; moreover, the adverse reactions, such as pain at the site of administration, liable cause of blood stasis, or even muscle necrosis and the like, can also be avoided.

Description

technical field [0001] The invention relates to a sarcophagus injection, a preparation method thereof and a sargassum injection for intravenous administration, belonging to the field of traditional Chinese medicine preparations. Background technique [0002] Zhongjiefeng, also known as Jiujiecha, Jiujiefeng, and Elderberry, is the whole plant of Chestnut Orchidaceae, a perennial evergreen herb or subshrub, and the whole plant is used as medicine; it is slightly warm in nature, bitter and pungent in taste; the main ingredients are Volatile oil (linalyl acetate, etc. in the oil) succinic acid, fumaric acid, coumarone, flavonoid glycosides, lactone, tannin, etc. Among them, volatile oil, succinic acid, fumaric acid, flavonoid glycosides, etc. are anti-tumor active ingredients. Shigella baumannii, typhoid bacillus, Escherichia coli, and Pseudomonas aeruginosa have strong inhibitory effects, and are used for the treatment of pneumonia, appendicitis, cellulitis, rheumatic arthral...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K9/08A61P31/04A61P19/02A61P29/00A61P35/00
CPCA61K9/0019A61K9/08A61K36/185A61K2236/331A61K2236/53A61K2236/55
Inventor 李芳凯
Owner 李芳凯
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