A three-dimensional bionic bone repair material and its preparation method

A technology of three-dimensional bionic bone and repair materials, which is applied in the medical field, can solve the problems of easy preparation of three-dimensional bionic fibrous bone repair materials, lack of directional layered structure of simulated bone tissue, and mechanical performance defects. The effect of increased toughness and easy operation

Active Publication Date: 2021-12-31
BEIJING NATON TECH GRP CO LTD
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Problems solved by technology

Chinese patent CN 103285424A discloses a three-dimensional fiber-based airgel tissue engineering scaffold and its preparation method. The fiber-based airgel prepared by this method has an isotropic porous structure and does not have an oriented layered structure for simulating bone tissue The fibers used in this method are polymer fibers, inorganic fibers or their blended fibers, and there are certain defects in mechanical properties.
Chinese patent CN102470195A discloses a porous structure of biological glass fiber, which requires high-temperature calcination in the preparation process, and the process is cumbersome
The methods disclosed in the above patents are difficult to realize the simple preparation of three-dimensional bionic fibrous bone repair materials

Method used

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  • A three-dimensional bionic bone repair material and its preparation method
  • A three-dimensional bionic bone repair material and its preparation method
  • A three-dimensional bionic bone repair material and its preparation method

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preparation example Construction

[0046] A method for preparing a three-dimensional bionic bone repair material according to an embodiment of the present invention comprises the following steps:

[0047] S1: Uniformly disperse the bioactive glass fibers in the dopamine solution to form a suspension;

[0048] S2: Inject the suspension into a two-way freezing device to freeze, so that the suspension forms a coagulated body;

[0049] S3: removing the solidified solvent in the solidified body to obtain the three-dimensional bionic bone repair material.

[0050] Further, in order to prepare bone repair materials containing polylactic acid-coated bioactive glass fibers, the following steps are also included before step S1:

[0051] S1': After uniformly dispersing the bioactive glass fiber in the polylactic acid solution, drying and removing the solvent to obtain polylactic acid-coated bioactive glass fiber;

[0052] The resulting polylactic acid-coated bioactive glass fibers and / or uncoated bioactive glass fibers ...

Embodiment 1 3

[0056] Embodiment 1 Preparation of three-dimensional bionic bone repair material

[0057] Add 1.5g of bioactive glass fiber to 100ml of a dopamine solution with a concentration of 5mg / ml, disperse it uniformly for 15 minutes with a homogenizer, stir the resulting dispersion at 300 rpm for 24 hours, and homogenize the obtained dispersion Inject the dispersion liquid into the two-way freezer, and freeze it in the two-way freezer, take it out after 15 minutes, put the obtained frozen sample into the freeze dryer, dry it for 24h at -50°C, and the vacuum degree is less than 20Pa, and then wash it with water to remove it. Unreacted dopamine and impurities were freeze-dried to obtain 1.52 g of three-dimensional bionic bone repair material. The volume density of the three-dimensional bionic bone repair material is 16mg / cm 3 , interlayer distance 20μm, porosity 90%.

Embodiment 2

[0058] Example 2 Preparation of polylactic acid composite three-dimensional bionic bone repair material

[0059] Dissolve 0.5g of polylactic acid in 100ml of chloroform solution, then add 2g of bioactive glass fiber, stir for 1 hour at 100 rpm, filter, and dry in an oven at 60°C for 10 hours to obtain polylactic acid Coated bioactive fiberglass. Add 1.5g of the above-mentioned fibers to 100ml of a dopamine solution with a concentration of 5mg / ml, disperse uniformly for 15 minutes with a homogenizer, stir the obtained dispersion at 300 rpm for 24 hours, and mix the obtained uniform dispersion Pour into the two-way freezer, freeze in the two-way freezer, take it out for 15 minutes, put the obtained frozen sample in a freeze dryer, dry it for 24 hours at -50°C, and vacuum less than 20Pa, then wash it with water to remove unreacted Dopamine and impurities in the mixture were freeze-dried to obtain 1.52 g of three-dimensional bionic bone repair material. The polylactic acid compo...

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Abstract

The invention provides a three-dimensional bionic bone repair material and a preparation method thereof. The three-dimensional bionic bone repair material forms a porous structure comprising a plurality of parallel oriented fiber layers through a two-way freezing method, and the oriented fiber layers are formed by interpenetrating bioactive glass fibers. Composed of a mesh plane, the interlacing points of bioactive glass fibers are interconnected by dopamine bonds. By simulating the ordered structure of bone tissue, it is beneficial to the repair of bone tissue. At the same time, the cross-linking of fibers realizes effective bonding and interconnection through dopamine cross-linking, and the preparation process is simple. The present invention can also prepare the polylactic acid composite three-dimensional bionic bone repair material by coating the polylactic acid on the bioactive glass fiber, increase the toughness of the bioactive glass fiber, and further improve the mechanical properties of the three-dimensional bionic bone repair material.

Description

technical field [0001] The invention relates to the medical field, in particular to a three-dimensional bionic bone repair material and a preparation method thereof. Background technique [0002] Bone defects are often caused by bone tumors, trauma, infection, and various congenital diseases. Currently, the treatment methods for bone defects mainly include autografting, allografting and artificial implants. Autografting has the disadvantages of additional surgical trauma and operation time, and complications such as infection and pain often occur in the bone harvesting area. Allogeneic transplantation may cause the spread of blood-borne diseases and cause immune responses to interfere with bone healing and other disadvantages. Artificial implants have the characteristics of good biocompatibility, bioabsorbability, osteoconductivity, osteoinductivity, and easy operation and use. Compared with the first two methods, they are increasingly showing their advantages. [0003] T...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/18A61L27/10A61L27/50A61L27/56
CPCA61L27/18A61L27/10A61L27/56A61L27/50A61L2430/02C08L67/04
Inventor 方宁曹晓艳董骧
Owner BEIJING NATON TECH GRP CO LTD
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