Papillary thyroid carcinoma distant metastasis mutation predicting model, method and system

Abstract

The invention provides a papillary thyroid carcinoma distant metastasis mutation predicting model, a predicting model method and a predicting model system. The papillary thyroid carcinoma distant metastasis mutation predicting model realizes high predicting accuracy which is higher than that of a currently reported model. Furthermore the papillary thyroid carcinoma distant metastasis mutation predicting model has high sensitivity and high specificity. Furthermore researching of the invention proves a fact that TERT starter mutation has no evident correlation with distant metastasis, and furthermore chr22q loss and gene fusion are remarkably correlated with distant metastasis. The samples of the invention are obtained from Chinese people, and foreign researching samples are obtained from the Western country people. Therefore the researching result of the invention has higher application value for the Chinese people.

Description

technical field

[0001] The invention belongs to biomedicine, in particular to a tumor detection model. Background technique

[0002] Thyroid cancer is the most common malignant tumor of the endocrine system, and it is also the malignant tumor with the fastest growing incidence in recent years. It not only threatens the health of people (especially women), but also greatly increases the burden on the government, society and families. Effective research on the prevention and control of thyroid cancer is a major livelihood issue facing our country. Papillary thyroid carcinoma is the main pathological type of thyroid cancer, accounting for more than 80-90%. The prognosis of papillary thyroid carcinoma varies greatly. Some patients, such as papillary thyroid microcarcinoma without risk factors, have an excellent prognosis. At present, there may be overtreatment, which wastes medical resources; while some patients with papillary thyroid carcinoma, if distant metastasis occurs, is...

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