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Preparation method of nerve conduit material based on polyhydroxyalkanoate/sodium alginate electrospun nanofiber

A polyhydroxyalkanoate and nerve conduit technology, which is applied in the field of nerve conduit materials and their preparation, can solve the problems of limitation, insufficient source of autologous transplantation and donor area, etc., and achieve the effect of improving electrospinning performance.

Active Publication Date: 2019-07-12
DALIAN POLYTECHNIC UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, autologous transplantation is the most commonly used clinical method for repairing peripheral nerve injuries, but autologous transplantation is limited by sources and insufficient donor sites.

Method used

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  • Preparation method of nerve conduit material based on polyhydroxyalkanoate/sodium alginate electrospun nanofiber
  • Preparation method of nerve conduit material based on polyhydroxyalkanoate/sodium alginate electrospun nanofiber
  • Preparation method of nerve conduit material based on polyhydroxyalkanoate/sodium alginate electrospun nanofiber

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The nerve guide material of polyhydroxyalkanoate / sodium alginate composite fiber is prepared according to the following method:

[0040] (1) carding chitosan fibers to form directional chitosan fibers;

[0041] (2) making the tubular mold (plastic tube) surface dipped in the sucrose bonding solution that mass percent concentration is 70%, and roll-coating on the surface of the oriented chitosan fiber, the chitosan fiber is evenly distributed on the tubular mold surface ;

[0042] (3) immerse the tubular mold formed with the chitosan fiber layer on the surface in the gelatin aqueous solution of 10% by mass percentage concentration, place it for a period of time, take out the tubular mold and dry it at room temperature, so that the chitosan fiber A gelatin layer is formed on the surface of the layer, and this step can be repeated several times, so that the thickness of the gelatin layer on the chitosan fiber layer surface reaches 1mm, and a tubular mold having a nerve gu...

Embodiment 2

[0049] The nerve guide material of polyhydroxyalkanoate / sodium alginate composite fiber is prepared according to the following method:

[0050] (1) carding chitosan fibers to form directional chitosan fibers;

[0051] (2) making the surface of the tubular mold (plastic tube) immersed in the sucrose bonding solution with a concentration mass concentration of 70%, and rolling coating on the surface of the oriented chitosan fiber, so that the chitosan fiber is evenly distributed on the surface of the tubular mold;

[0052] (3) will form the tubular mold that has chitosan fiber layer on the surface and be immersed in the gelatin aqueous solution of 10% in mass concentration, place for a period of time, take out tubular mold and dry at room temperature, so that on the surface of chitosan fiber layer Form the gelatin layer, this step can be repeated several times, make the thickness of the gelatin layer on the chitosan fiber layer surface reach 1mm, must form the tubular mold that h...

Embodiment 3

[0058] The nerve guide material of polyhydroxyalkanoate / sodium alginate composite fiber is prepared according to the following method:

[0059] (1) carding chitosan fibers to form directional chitosan fibers;

[0060] (2) making the surface of the tubular mold (plastic tube) immersed in the sucrose bonding solution with a concentration mass concentration of 70%, and rolling coating on the surface of the oriented chitosan fiber, so that the chitosan fiber is evenly distributed on the surface of the tubular mold;

[0061] (3) will form the tubular mold that has chitosan fiber layer on the surface and be immersed in the gelatin aqueous solution of 10% in mass concentration, place for a period of time, take out tubular mold and dry at room temperature, so that on the surface of chitosan fiber layer Form the gelatin layer, this step can be repeated several times, make the thickness of the gelatin layer on the chitosan fiber layer surface reach 1mm, must form the tubular mold that h...

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Abstract

The invention discloses a preparation method of a nerve conduit material based on a polyhydroxyalkanoate / sodium alginate electrospun nanofiber. The nerve conduit material is obtained by winding the surface of a nerve conduit substrate with the nanofiber obtained by electrospinning a spinning solution, wherein the spinning solution is a mixed solution of a sodium alginate aqueous solution, alkyl glycoside, an organic solvent and polyhydroxyalkanoate, and the nerve conduit substrate is obtained by coating a chitosan fiber layer formed on the surface of a tubular mold with gelatin. According to the method, after the alkyl glycoside coats the surface of the sodium alginate, the sodium alginate is compounded with the polyhydroxyalkanoate to prepare the spinning solution, the electrospinning property of the spinning solution is improved, processing is facilitated, and the biocompatibility is good.

Description

technical field [0001] The invention belongs to the technical field of preparation of medical composite fibers, and in particular relates to nerve guide materials based on polyhydroxyalkanoate / sodium alginate electrospun nanofibers and a preparation method thereof. Background technique [0002] Human body trauma is inevitable in life, and the frequency of human body trauma in people's life is increasing year by year. Moreover, in human trauma, peripheral nerve damage accounts for about 5%. Therefore, nerve repair has become an important problem that needs to be solved urgently in the clinical and scientific circles. At present, autologous transplantation is the most commonly used clinical method to repair peripheral nerve injury, but autologous transplantation is limited by sources and insufficient donor sites. Thus, tissue engineered nerve conduits came into being. [0003] Polyhydroxyalkanoate (P(3HB-co-4HB)) is a degradable biopolyester obtained by microorganisms, and i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/18A61L27/50D01F8/18D01F8/14D01F1/10D01D5/00
CPCA61L27/18A61L27/20A61L27/50A61L2400/12D01D5/003D01D5/0092D01F1/10D01F8/14D01F8/18C08L5/04C08L67/04
Inventor 郭静孙范忱刘赣东管福成
Owner DALIAN POLYTECHNIC UNIVERSITY
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