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A solvent-induced hyaluronic acid-based shape memory hydrogel and its preparation method
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A hyaluronic acid and hydrogel technology, applied in the field of solvent-induced shape memory hydrogel and its preparation, can solve the problems of weak mechanical properties and limited applications, and achieve simple and easy preparation methods and non-toxic and non-toxic processes. harmful, good mechanical properties
Active Publication Date: 2021-03-26
NANJING FORESTRY UNIV
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However, the weak mechanical properties of hydrogels greatly limit their applications.
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Embodiment 1
[0024] A solvent-induced shape memory hydrogel, which includes the following raw materials by weight: 2 mL of an aqueous solution of 5 g / L nanocellulose, and 8 mL of an aqueous solution of 5 g / L hyaluronic acid.
[0025] Above-mentioned each raw material is prepared according to the following steps:
[0026] 1) Mixing the cellulose nanofiber aqueous solution and the hyaluronic acid aqueous solution in proportion;
[0027] 2) Prepare the mixture mixed in step 1) in a mold under an acidic steam bath (steam bath produced by pure acetic acid) for 12 hours to obtain a composite hydrogel, which is the solvent-induced hyaluronic acid-based shape memory hydrogel.
[0028] The shape memory test is done to the sample obtained in this embodiment:
[0029] After the strip-shaped hydrogel was replaced in tert-butanol at 30°C for 12 hours, the shape of the hydrogel was fixed and round, and then the hydrogel was placed in distilled water for 3 minutes at room temperature, and the hydrogel ...
Embodiment 2
[0031] A solvent-induced shape memory hydrogel, which includes the following raw materials by weight: 3 mL of an aqueous solution of 5 g / L nanocellulose, and 7 mL of an aqueous solution of 5 g / L hyaluronic acid.
[0032] The preparation method of the shape memory hydrogel of this example is the same as that of Example 1.
[0033] The shape-memory hydrogel of this example has substantially the same mechanical properties and shape-memory properties as Example 1.
Embodiment 3
[0035] A solvent-induced shape memory hydrogel, which includes the following raw materials by weight: 4 mL of an aqueous solution of 5 g / L nanocellulose, and 6 mL of an aqueous solution of 5 g / L hyaluronic acid.
[0036] The preparation method of the shape memory hydrogel of this example is the same as that of Example 1.
[0037] The shape-memory hydrogel of this example has substantially the same mechanical properties and shape-memory properties as Example 1.
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Abstract
The invention discloses a preparation method of hyaluronic acid-based shape memory hydrogel based on solvent induction. An aqueous solution of nano-crystalline cellulose and an aqueous solution of hyaluronic acid react in an acidic steam bath for 5 to 12 hours. The method of the invention effectively utilizes physical cross-linking to realize composite gel preparation of nano-crystalline celluloseand hyaluronic acid, and the prepared composite hydrogel shrinks in shape in tertiary butanol under the influence of the solvent effect to obtain temporarily shaped hydrogel; and the temporarily shaped hydrogel then is put into water and quickly restores the original shape of the hydrogel to achieve the shape memory effect of the hydrogel. The composite hydrogel not only has the relatively high mechanical properties of the nano-crystalline cellulose and the water-retaining functional characteristic of the hyaluronic acid, and no toxic and harmful effects are caused in the whole preparation process; and the preparation method has a wide application prospect in the aspects of drug delivery, material implantation and the like.
Description
technical field [0001] The invention belongs to the field of preparation of natural polymer nanofibers, and in particular relates to a solvent-induced shape memory hydrogel and a preparation method thereof. Background technique [0002] A hydrogel is a substance that swells in water but does not dissolve. At present, the preparation and application of new hydrogels are the main research fields of hydrogels. Over the past few decades, hydrogels have been widely used in biomedicine, such as medical devices such as drug carriers, wound dressings, cartilage replacements, and artificial kidney membranes. However, the weak mechanical properties of hydrogels greatly limit their applications. As a medical material, in addition to certain biocompatibility and non-toxicity, it must also have certain mechanical strength and deformation recovery performance. Traditional hydrogels mainly rely on chemical cross-linking, but in the research of new hydrogels, the use of physical cross-li...
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