Implantable devices for drug delivery with reduced burst release

An implanted device and delivery technology, applied in drug delivery, drug devices, medical preparations containing active ingredients, etc., can solve problems such as prohibition, inconvenient compliance with drug regimens, and intolerable intestinal drug delivery

Pending Publication Date: 2019-07-16
TITAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compliance with extended dosing regimens may often be inconvenient or difficult
For example, patients with impaired cognitive function (due to Alzheimer's disease or other disorders) may not be able to reliably self-administer medication, requiring caregivers to ensure proper intake
Furthermore, enteral drug delivery is sometimes poorly tolerated or contraindicated for patients with specific indications

Method used

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  • Implantable devices for drug delivery with reduced burst release
  • Implantable devices for drug delivery with reduced burst release
  • Implantable devices for drug delivery with reduced burst release

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0141] Preparation of device of the present invention

[0142] In some embodiments, implantable devices of the present invention can be prepared by coextruding the drug-containing core and porogen-containing shell of the device. The pharmaceutical substance is reduced to fine particles by milling (eg, ball milling, impact milling), spray drying, solvent precipitation, sieving, or other method or combination of methods known in the art to produce fine particles. The drug can be combined with a polymer that is also made into fine particles to form the mixture used to make the drug-containing core. Likewise, porogen-containing shells are prepared by blending fine particles of polymer with porogen particles of the desired size. Each blended mixture is heated to a temperature suitable for extrusion, such as the softening point of the polymer. At this point, optionally and if necessary, either or both of the softened mixtures can be homogenized. The mixture is then coextruded, fo...

Embodiment approach 1

[0161] Embodiment 1. An implantable device for delivering a drug substance comprising a core comprising a first polymer material and a core drug substance; and a shell comprising a second polymer material and a porogen material; wherein, with The implantable device has a reduced burst release compared to a comparative device made entirely of the first polymer material and the core drug substance.

Embodiment approach 2

[0162] Embodiment 2. The implantable device of embodiment 1, wherein the shell is a drug-free layer.

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Abstract

The invention provides implantable drug delivery devices comprising a core comprising a polymer (or polymer blend) and one or more drugs or pharmaceutical substances, and an outer shell comprising a polymer (or polymer blend) and one or more porogen materials. The invention reduces burst release of drug. Pharmaceuticals such as triiodothyronine (T3) or ropinirole can be delivered by the devices.

Description

[0001] Cross References to Related Applications [0002] This patent application claims the benefit of priority to U.S. Provisional Patent Application No. 62 / 404,643, filed October 5, 2016. The entire content of this application is incorporated herein by reference. technical field [0003] The present invention provides devices that can be implanted in a patient to release a pharmaceutical substance such as triiodothyronine for a prolonged period of time with reduced, minimal or no burst release. [0004] Background of the invention [0005] Many patients require regular, long-term administration of drugs or pharmaceutical substances. Effective treatment generally requires daily ingestion of one or more tablets for an extended period of time. For example, patients undergoing thyroidectomy, a common treatment for thyroid cancer, must take oral thyroxine tablets for the rest of their lives. Typically, patients take levothyroxine (T 4 ), which is converted in vivo to triiodo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/00A61F13/00A61F9/00
CPCA61K9/0024A61K9/145A61K9/146A61M31/002A61M37/0069A61P25/16A61K45/06A61K31/122A61K31/155A61K31/198A61K31/404A61K31/4458A61K31/485A61K31/506A61K31/65A61K31/675A61K31/7068A61K38/26Y02A50/30A61K2300/00A61K9/0092A61K31/4045A61K31/513B29C48/21B29C48/06A61K9/4808A61K9/4816A61K9/4833A61K31/197B29K2001/08B29K2023/083B29K2105/0035B29K2995/006B29L2031/753
Inventor R·A·帕特尔S·斯里达兰S·R·博斯勒
Owner TITAN PHARMA
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