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Composite celery seed oil self-emulsifying soft capsule with anti-gout effect and preparation method thereof

A technology of self-emulsifying soft capsules and celery seed oil, applied in the field of medicine, can solve the problems of low bioavailability, difficult to solve the volatile problem of celery seed oil, etc., and achieves improved bioavailability, excellent storage stability, The effect of reducing dosage

Inactive Publication Date: 2019-07-23
江苏圣典医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Celery seed oil also contains a large amount of volatile terpenoids in addition to a certain amount of fatty acid, so it is necessary to pay attention to the volatility of celery seed oil during the preparation process. Compared with capsule preparations, not only its bioavailability is relatively low, but also the volatility of celery seed oil is difficult to solve

Method used

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  • Composite celery seed oil self-emulsifying soft capsule with anti-gout effect and preparation method thereof
  • Composite celery seed oil self-emulsifying soft capsule with anti-gout effect and preparation method thereof
  • Composite celery seed oil self-emulsifying soft capsule with anti-gout effect and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1: Compound celery seed oil self-emulsifying soft capsule preparation one

[0036] 1. The ingredients are as shown in Table 1:

[0037] Table 1 Composition of compound celery seed oil self-emulsifying soft capsule 1

[0038]

[0039] 2. Preparation method

[0040] (1) Blending of compound celery seed oil: Take celery seed oil as shown in Table 1, add it to the ingredients container, and add royal rice oil, corn oil, and vitamin E in sequence at 35°C, and stir at a slow speed for 25 minutes. Obtain compound celery seed oil after filtering.

[0041] (2) As shown in Table 1, mix soybean lecithin and glycerin, use a shearing machine (8000 rpm), stir twice, the first time for 5 minutes, and the second time for 2 minutes to make it evenly dispersed, add warm The compound celery seed oil is stirred 3 times, each time for 5 minutes, and filtered to form a uniform liquid that is the self-emulsifying system of the compound celery seed oil.

[0042] (3) As shown ...

Embodiment 2

[0046] Embodiment 2: Compound celery seed oil self-emulsifying soft capsule preparation two

[0047] 1. The ingredients are as shown in Table 2:

[0048] Table 2 Composition of compound celery seed oil self-emulsifying soft capsules 2

[0049]

[0050] 2. Preparation method

[0051] (1) Blending of compound celery seed oil: take celery seed oil as shown in Table 2, add it to the ingredient container, and add Eucommia ulmoides seed oil, corn oil, vitamin E, and vitamin C in sequence at 35°C, and stir slowly After 20 minutes, compound celery seed oil was obtained after filtering.

[0052] (2) As shown in Table 2, mix egg yolk lecithin, ethanol, and glycerin, and use a shearing machine (8000 rpm), stir twice, the first time for 5 minutes, and the second time for 2 minutes to make it evenly dispersed, add The warm compound celery seed oil was stirred 3 times for 5 minutes each time, and filtered to form a uniform liquid that is the self-emulsifying system of the compound cel...

Embodiment 3

[0057] Embodiment 3: Preparation of compound celery seed oil self-emulsifying soft capsule three

[0058] 1. The ingredients are as shown in Table 3:

[0059] Table 3 Composition of compound celery seed oil self-emulsifying soft capsules 3

[0060]

[0061] 2. Preparation method

[0062] (1) Blending of compound celery seed oil: Take celery seed oil as shown in Table 3, add it to the ingredient container, and add imperial rice oil, Eucommia seed oil, walnut oil, vitamin E, and vitamin C in sequence at 30°C , stirred at a slow speed for 25 minutes, and obtained compound celery seed oil after filtering.

[0063] ⑵According to Table 2, mix liquid lecithin, ethanol, and glycerin, use a shearing machine (8000 rpm), stir twice, the first time for 5 minutes, and the second time for 2 minutes, to make it disperse evenly, add The warm compound celery seed oil was stirred 3 times for 5 minutes each time, and filtered to form a uniform liquid that is the self-emulsifying system of ...

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Abstract

The present invention discloses a composite celery seed oil self-emulsifying soft capsule with an anti-gout effect and a preparation method thereof. The preparation is prepared from celery seed oil compounded with vegetable oil having the anti-gout effect and / or capable of significantly enhancing the anti-gout effect of the celery seed oil, a surfactant, a co-surfactant and other drugs into a uniform clear solution. The easily volatile celery seed oil is compounded with the vegetable oil not easily volatile and having the anti-gout effect or capable of significantly enhancing the effect undersuitable temperature conditions into composite celery seed oil, and then the composite celery seed oil, surfactant, co-surfactant and other drugs are prepared into the soft capsule. The stable celeryseed oil or composite celery seed oil self-emulsifying system can be obtained, bioavailability of the composite celery seed oil or celery seed oil and other drugs can be improved, and besides, the composite celery seed oil self-emulsifying soft capsule is fast in effects, overcomes defects that celery seed oil common preparations are relatively low in bioavailability and easily volatile, and significantly enhances the anti-gout effect of the celery seed oil.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a celery seed oil or compound celery seed oil self-emulsifying soft capsule with anti-gout effect and a preparation method thereof. Background technique [0002] Celery seed oil is a hydrophobic yellow-green translucent oil extracted from celery seeds. Celery seed is the seed of celery (Apium graveolens L.). Celery is an annual or biennial herb plant, which is cultivated all over the world. Celery not only has high edible value, but the oil extracted from its fruit is a yellow-green translucent oily liquid with a unique fresh aroma. It can be used as a seasoning spice in seasoning Widely used in pharmaceuticals, medicine, cosmetics and other fields. Celery seed oil is different from general vegetable seed oil. In addition to the fatty acid components contained in general vegetable seed oil, celery seed oil also contains a large amount of volatile oil (that is, cele...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K36/66A61K9/48A61K47/44A61P19/06A61P19/02
CPCA61K9/4858A61K36/23A61K36/46A61K36/52A61K36/66A61K36/899A61P19/02A61P19/06A61K2300/00
Inventor 陈苏云
Owner 江苏圣典医药科技有限公司
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