A preparation method of nano-loaded zinc hydroxyapatite porous bioceramics

A nano-hydroxyapatite and hydroxyapatite technology, applied in ceramic products, other household appliances, household appliances, etc., can solve problems such as long-term pain at the bone graft site, mismatch of artificial bone osteogenesis rate, and bone graft delay. , to improve the osteogenic induction ability, good osteogenic induction ability, and promote the effect of osteogenesis

Active Publication Date: 2021-11-09
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Delayed union or nonunion of bone graft, mismatch between degradation of artificial bone and bone formation rate, fragmentation and deformation of bone graft material, loss of height of bone block due to collapse after bone graft, infection after bone graft, long-term sinus formation, bone graft Long-term pain and other problems

Method used

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  • A preparation method of nano-loaded zinc hydroxyapatite porous bioceramics
  • A preparation method of nano-loaded zinc hydroxyapatite porous bioceramics
  • A preparation method of nano-loaded zinc hydroxyapatite porous bioceramics

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Experimental program
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Effect test

Embodiment 1

[0026] (1) Using nano-zinc with a purity of ≥99.9% and a particle size of 50-60nm and nano-hydroxyapatite powder with a purity of ≥99.7% and a particle size of 80-100nm as raw materials, weigh nano-zinc at a mass ratio of 1:99 and nano-hydroxyapatite powder.

[0027] (2) Put the powder raw material weighed in step (1) into a vacuum ball mill tank, add stainless steel balls, absolute ethanol and polyethylene glycol as a dispersant, vacuumize to 10Pa, and then fill with argon with a purity of 99.999% Air, placed on a planetary ball mill, ball milled at a speed of 300r / min for 8h, dried and ground in a vacuum oven at 60°C to obtain a hydroxyapatite composite powder loaded with nano-zinc.

[0028] (3) The hydroxyapatite composite powder loaded with nano-zinc obtained in step (2) was uniformly mixed with the powder of ammonium bicarbonate, a pore-forming agent with a purity AR and an average particle size of 500 μm, at a mass ratio of 75:25 to obtain a mixed powder.

[0029] (4) P...

Embodiment 2

[0032] Using nano-zinc with a purity of ≥99.9% and a particle size of 50-60nm and nano-hydroxyapatite powder with a purity of ≥99.7% and a particle size of 80-100nm as raw materials, weigh nano-zinc and nano-hydroxyapatite at a mass ratio of 3:97 Apatite powder, other process steps and parameters are consistent with embodiment 1.

Embodiment 3

[0034] Using nano-zinc with a purity of ≥99.9% and a particle size of 50-60nm and nano-hydroxyapatite powder with a purity of ≥99.7% and a particle size of 80-100nm as raw materials, weigh nano-zinc and nano-hydroxyapatite at a mass ratio of 5:95 Apatite powder, other process steps and parameters are consistent with embodiment 1.

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Abstract

The invention discloses a preparation method of hydroxyapatite porous bioceramics loaded with nanometer zinc, belonging to the technical field of preparation of biomedical materials. The method of the present invention is to weigh nano-hydroxyapatite (99%-97%) and nano-zinc (1%-7%) powder according to the mass ratio, and then perform ball milling to obtain a composite powder, and mix the composite powder with a pore-forming agent The ammonium bicarbonate is mixed, and after being uniformly mixed, the green body is obtained by pressing, and the porous bioceramics of hydroxyapatite loaded with nanometer zinc is prepared by using the discharge plasma sintering technology. The porous bioceramic prepared by the present invention not only has uniform and pure composition, the porosity of the material is controllable between 40-70%, the compressive strength is 82-162Mpa, and the pore size is 50-600μm; and the addition of zinc can significantly improve the porosity. Osteogenic induction ability of bioceramics, the degradation rate matches the osteogenesis rate; it is suitable for bone scaffolding, filling and repairing materials.

Description

technical field [0001] The invention relates to a method for preparing nano-loaded zinc hydroxyapatite porous bioceramics, which belongs to the technical field of biomedical material preparation. Background technique [0002] In recent years, with the rapid development of my country's national economy, the improvement of people's living standards, the aging of the population, and the significant improvement of medical and health standards, more and more orthopedic patients are caused by work-related injuries, traffic accidents, bone tumors, bone tuberculosis and other diseases. At present, the clinically used bone materials are mainly autologous bone and allogeneic bone. Autologous bone is the most ideal bone material, but there are problems such as insufficient source of autologous bone and complications of the donor site (such as infection, skin necrosis, and permanent defect of the donor site); The bone material of choice, but it has problems such as graft rejection, dis...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C04B38/02C04B35/447C04B35/626C04B35/64
CPCC04B35/447C04B35/6261C04B35/64C04B38/02C04B2235/3284C04B2235/5454C04B2235/6562C04B2235/6567C04B2235/666
Inventor 张玉勤朱斌孟增东罗丽琳何远怀
Owner KUNMING UNIV OF SCI & TECH
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