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Stable isotope 74Se labeled quantum dots and preparation method thereof

A technology of stable isotopes and quantum dots, applied in chemical instruments and methods, nanotechnology, nano-optics, etc., can solve the problems of inability to accurately track the distribution and metabolism of selenium elements, and achieve the effect of good repeatability, simple operation and reaction conditions

Active Publication Date: 2019-08-09
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The second object of the present invention is to provide the stable isotope 74 A method for preparing Se-labeled metal selenide quantum dots, so as to overcome the defects that the existing labeling and measurement technologies cannot accurately track the distribution and metabolism of selenium in the quantum dots

Method used

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  • Stable isotope 74Se labeled quantum dots and preparation method thereof
  • Stable isotope 74Se labeled quantum dots and preparation method thereof
  • Stable isotope 74Se labeled quantum dots and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0040] Embodiment 1: earlier 2 mmol (0.1580 g) stable isotope 74 After adding 6 mmol 70% nitric acid to Se powder, heat it in a water bath for 90 o C to fully dissolve after reacting for 1 h. stable isotope 74 The mixed solution after the Se powder oxidation reaction was placed on ice, and the pH of the system was adjusted to 9–10 with 10 mol / L NaOH. Then, under the condition of nitrogen protection, 90 mL (0.2 mol / L) sodium borohydride aqueous solution was added and reacted for 30 min under magnetic stirring conditions to prepare 74 Se aqueous phase reaction solution.

[0041] Add 0.4 mmol (0.0679 g) silver nitrate solid to 30 mL oleylamine and 70 mL toluene, 40 o C, heat and stir for 15 min~30 min, until the silver nitrate is completely dissolved in oleylamine, then add 30 mL of n-dodecanethiol and 70 mL of 74 Se aqueous phase reaction solution (wherein NaH 74 The amount of Se is 0.15 mmol) After vigorously stirring the reaction for 5min, the above-mentioned mixed solut...

Embodiment 2

[0044] Embodiment 2: first 2 mmol (0.1580 g) stable isotope 74 After adding 6 mmol 70% nitric acid to Se powder, heat it in a water bath for 90 o C to fully dissolve after reacting for 1 h. stable isotope 74 The mixed solution after the Se powder oxidation reaction was placed on ice, and the pH of the system was adjusted to 9-10 with 10 mol / L NaOH. Then, under the condition of nitrogen protection, 90 mL (0.2 mol / L) sodium borohydride aqueous solution was added and reacted for 30 min under magnetic stirring conditions to prepare 74 Se aqueous phase reaction solution.

[0045] Add 0.4 mmol (0.0513 g) cadmium oxide solid to 30 mL oleylamine and 70 mL toluene, 40 o C, heat and stir for 15 min~30 min, until the cadmium oxide is completely dissolved in oleylamine, then add 30 mL of n-dodecanethiol and 70 mL of 74 Se aqueous phase reaction solution (wherein NaH 74 The amount of Se is 0.15 mmol) After vigorously stirring the reaction for 5min, the above-mentioned mixed solution ...

Embodiment 3

[0048] Embodiment 3: first 2 mmol (0.1580 g) stable isotope 74 After adding 6 mmol 70% nitric acid to Se powder, heat it in a water bath for 90 o C to fully dissolve after reacting for 1 h. stable isotope 74 The mixed solution after the Se powder oxidation reaction was placed on ice, and the pH of the system was adjusted to 9–10 with 10 mol / L NaOH. Then, under the condition of nitrogen protection, 90 mL (0.2 mol / L) sodium borohydride aqueous solution was added and reacted for 30 min under magnetic stirring conditions to prepare 74 Se aqueous phase reaction solution.

[0049]Add 0.4 mmol (0.0734 g) zinc acetate solid to 30 mL oleylamine and 70 mL toluene, 40 o C, heat and stir for 15 min~30 min, until zinc acetate is completely dissolved in oleylamine, then add 30 mL of octyl mercaptan and 70 mL of 74 Se aqueous phase reaction solution (wherein NaH 74 The amount of Se is 0.15 mmol) After vigorously stirring the reaction for 5 min, the above mixed solution was transferred ...

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Abstract

The invention discloses stable isotope 74Se labeled quantum dots and a preparation method thereof. The stable isotope 74Se labeled quantum dots are of a nanometer spherical structure composed of a binary compound. By means of the method, the stable isotope 74Se labeled silver selenide quantum dots and cadmium selenide quantum dots which are uniform in size and stable can be prepared, and the method can be popularized in other selenium-containing nanometer materials. The preparation method is simple in reaction condition and operation and high in repeatability, the particle size can be controlled, and the fluorescence-emission wavelength can be controlled. The stable isotope 74Se labeling method can achieve long-time labeling and tracing of the selenium in the quantum dots in the body, andthe background interference of endogenous selenium is greatly reduced.

Description

technical field [0001] The present invention relates to stable isotopes 74 The invention discloses Se-marked metal selenide quantum dots and a preparation method thereof, belonging to the technical field of nanometer material preparation. Background technique [0002] Due to their excellent physical and chemical properties, quantum dots have been widely used in the field of biomedicine. For example, they can be used as non-invasive imaging agents to realize medical imaging, as diagnostic and therapeutic tools to realize drug delivery, to mark viruses to track invasion processes and as sensors to monitor Changes in intracellular biological signals. Biosafety evaluation of nanomaterials is a necessary prerequisite for their practical application, and tracking the metabolism and distribution of quantum dots in organisms is an important part of it. At present, the methods commonly used to trace quantum dots are mainly fluorescence analysis and radioactive isotope labeling, but...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/02C09K11/88B82Y20/00B82Y30/00
CPCC09K11/025C09K11/881C09K11/883B82Y20/00B82Y30/00
Inventor 王海芳唐欢张军正刘春园陈星竹曹傲能
Owner SHANGHAI UNIV
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