A kind of ethanol foam sclerosing agent used in the treatment of abnormal blood vessels and its preparation method

一种泡沫硬化剂、乙醇的技术，应用在治疗脉管异常的乙醇泡沫硬化剂及制备领域，能够解决治疗作用不及、限制广泛应用、副作用严重等问题，达到良好生物安全性、提高均一性、半衰期长的效果

Active Publication Date: 2020-09-01
SHANDONG UNIV QILU HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the above three sclerosing agents, currently only polidocanol can form foam, while absolute alcohol and bleomycin cannot form foam
The inventors found that although absolute ethanol is recognized as the most powerful sclerosing agent, the side effects are the most serious and most likely to occur, mainly tissue necrosis, which seriously limits its wide application
Polidocanol has a mild effect, and although its therapeutic effect is significantly improved after being made into a foam, its therapeutic effect is far less than that of absolute ethanol

Method used

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  • A kind of ethanol foam sclerosing agent used in the treatment of abnormal blood vessels and its preparation method
  • A kind of ethanol foam sclerosing agent used in the treatment of abnormal blood vessels and its preparation method
  • A kind of ethanol foam sclerosing agent used in the treatment of abnormal blood vessels and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 40.5 g of absolute ethanol, 56.7 g of water, 0.6 g of Tween 80, 1.1 g of egg yolk lecithin, and 1.1 g of hyaluronic acid were mixed respectively. Draw the mixed solution into one syringe, and use another syringe to draw sterile air. At room temperature, use the Tessari method, a common clinical foam production method, to prepare ethanol foam according to the ratio of liquid: air = 1:3 to form a uniform foam. , Stable and dense foam, and the half-life of the foam is above 1min.

Embodiment 2

[0045] 37.8 g of absolute ethanol, 59.9 g of water, 0.6 g of Tween 80, 1 g of egg yolk lecithin, and 0.7 g of hyaluronic acid were mixed. Draw the mixed solution into one syringe, and use another syringe to draw sterile air. At room temperature, use the Tessari method, a common clinical foam production method, to prepare ethanol foam according to the ratio of liquid: air = 1:3 to form a uniform foam. , Stable and dense foam, and the half-life of the foam is above 1min.

Embodiment 3

[0047] 35 g of absolute ethanol, 62.6 g of water, 0.6 g of Tween 80, 1.1 g of egg yolk lecithin, and 0.7 g of hyaluronic acid were mixed. Draw the mixed solution into one syringe, and use another syringe to draw sterile air. At room temperature, use the Tessari method, a common clinical foam production method, to prepare ethanol foam according to the ratio of liquid: air = 1:3 to form a uniform foam. , Stable and dense foam, and the half-life of the foam is above 1min.

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Abstract

The invention relates to an ethanol foam hardening agent for abnormal blood vessels and a preparation method, which comprises absolute ethanol, water, Tween 80 and a stabilizer. Also includes hyaluronic acid, absolute ethanol 32‑42%, Tween 80 0.5‑2%, egg yolk lecithin 0‑25 (excluding 0), hyaluronic acid 0‑2% (excluding 0), the rest is water . The stabilizer is hyaluronic acid or glycerin, and the Tessari method is used to prepare the foam, which not only does not change the original therapeutic effect of ethanol, but also significantly reduces its side effects.

Description

technical field [0001] The invention belongs to the technical field of preparation of sclerosing agent materials, and in particular relates to an ethanol foam sclerosing agent used for treating abnormal blood vessels and a preparation method thereof. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Vascular anomaly is a major disease that seriously endangers human health, including venous malformation, arteriovenous malformation, hemangioma and lymphatic malformation, among which venous anomaly is the most common. The disease can occur in any part of the human body, about 60% of which occur in the maxillofacial region. Depending on the location and severity of the disease...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/12A61K47/36A61K47/26A61K47/24A61K31/045A61P9/14A61P35/00
CPCA61K9/122A61K47/36A61K47/26A61K47/24A61K31/045A61P9/14A61P35/00A61K47/10A61K9/0019
Inventor 刘少华张涵恕杨爱军
Owner SHANDONG UNIV QILU HOSPITAL
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