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Method for rapidly separating and measuring ground-state iron in ferrous bisglycinate chelate

A technology of ferrous glycinate and ground state, which is applied in the field of analysis, can solve the problem of no reference for the determination of ground state iron, and achieve the effect of fast operation, high detection sensitivity and simple steps

Inactive Publication Date: 2019-08-20
NOVAST LABORATORIES (CHINA) LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The content of ferrous glycinate in ferrous glycinate and the determination of ferric iron impurities can refer to the chapter of ferrous fumarate in the United States Pharmacopoeia, but there is no reference for the determination of ground state iron, and the determination of ground state iron needs to consider the content of ferrous iron and ferric iron Therefore, it is of practical significance to develop an analytical method to realize rapid separation, enrichment and determination of ground state iron in ferrous glycinate

Method used

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  • Method for rapidly separating and measuring ground-state iron in ferrous bisglycinate chelate
  • Method for rapidly separating and measuring ground-state iron in ferrous bisglycinate chelate
  • Method for rapidly separating and measuring ground-state iron in ferrous bisglycinate chelate

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Embodiment 1

[0027] Determination of ground state iron content in ferrous glycinate:

[0028] Ferrous Glycinate Supplier: Albion

[0029] (1) Instruments and conditions

[0030] Spectrometer: Perkin Elmer inductively coupled plasma optical emission spectrometer (ICP-OES) and workstation;

[0031]

[0032] (2), experimental steps

[0033] Preparation of 3% dilute nitric acid:

[0034] Dilute 50ml of concentrated nitric acid with water to 1L.

[0035] Preparation of the test solution:

[0036] Accurately weigh 100mg of ferrous glycinate into a 50ml plastic centrifuge tube, add 40ml of water, vortex for 5 minutes, ultrasonic for 5 minutes, then centrifuge at 3500 rpm for 10 minutes, discard the supernatant. Then add 40ml of water, vortex for 5 minutes, sonicate for 5 minutes, then centrifuge at 3500 rpm for 10 minutes, discard the supernatant. Add 40ml of water again, and repeat the above steps until the ferrous iron, ferric iron and other impurities are eluted (the supernatant is a ...

Embodiment 2

[0050] Determination of ground state iron content in ferrous glycinate:

[0051] Ferrous glycinate supplier: Tai Ruixin

[0052] (1) Instruments and conditions

[0053] Spectrometer: Perkin Elmer inductively coupled plasma optical emission spectrometer (ICP-OES) and workstation;

[0054]

[0055] (2), experimental steps

[0056] Preparation of 3% dilute nitric acid:

[0057] Dilute 50ml of concentrated nitric acid with water to 1L.

[0058] Preparation of the test solution:

[0059]Accurately weigh 100mg of ferrous glycinate into a 50ml plastic centrifuge tube, add 40ml of water, vortex for 5 minutes, ultrasonic for 5 minutes, then centrifuge at 3500 rpm for 10 minutes, discard the supernatant. Then add 40ml of water, vortex for 5 minutes, sonicate for 5 minutes, then centrifuge at 3500 rpm for 10 minutes, discard the supernatant. Add 40ml of water again, and repeat the above steps until the ferrous iron, ferric iron and other impurities are eluted (the supernatant is...

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Abstract

The invention discloses a method for rapidly separating and measuring ground-state iron in ferrous bisglycinate chelate. According to the method, ferrous bisglycinate chelate to be detected is arranged in a centrifuge tube; water is added to the centrifuge tube; spinning and ultrasonic sound treatment are carried out, and then centrifugation is carried out; a supernate is poured; repeated washingis carried out so as to remove a ferrous bisglycinate chelate solution; and iron is left as a subsequent determination sample; during this period, magnet adsorption can be utilized outside the centrifugal tube, so that the ground-state iron can be gathered, and therefore, the ground-state iron can be better separated and enriched; concentrated nitric acid and 3% dilute nitric acid are added to dissolve the iron, then an obtained solution is transferred into a 100 ml bottle, and volume fixing is carried out on the solution, so that a test substance solution can be obtained; a reference substance solution is prepared; an inductive coupling plasma emission spectrometer is adopted to analyze a reference substance and a test substance; and a computer system is used for acquiring data. The method has the advantages of high specificity, rapid analysis, high anti-interference performance and high sensitivity.

Description

technical field [0001] The invention specifically relates to an analysis method, a method for rapidly separating and measuring ground state iron in ferrous glycinate. Background technique [0002] Ferrous glycinate [Fe(Gly) 2 ] is an amino acid chelate, iron is the main component of hemoglobin, myoglobin, and various enzyme systems, and plays an important role in nutrition and immunity in the body. Ferrous glycinate is an important nutritional additive. Compared with the first generation (iron salt of inorganic acid) and the second generation (ferric salt of organic acid), ferrous glycinate has good stability, easy absorption, and no iron smell , no gastrointestinal irritation, no toxic side effects, high bioavailability, etc., is the third generation of iron supplements, which can supplement iron and glycine at the same time. [0003] The main component of ferrous glycinate is ferrous glycinate (content greater than 77%), followed by citric acid (content greater than 17%)...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/73
CPCG01N21/73
Inventor 胡成松殷敏敏张晖吴毓渊房杏春张国华
Owner NOVAST LABORATORIES (CHINA) LTD
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