In-vivo closed-loop extraction device for circulating tumor cells (CTC)

Abstract

The invention discloses an in-vivo closed-loop extraction device for circulating tumor cells (CTC). The device comprises a blood collection unit, wherein the blood collection unit is connected with aprimary separation unit through a first blood transfusion tube; the primary separation unit is connected with a fine separation unit or a storage unit through a second blood transfusion tube; the primary separation unit is further connected with a reverse-transfusion unit through a third blood transfusion tube; the primary separation unit is used for separating blood into components containing thecirculating tumor cells and components containing no circulating tumor cells; the fine separation unit is connected with the reverse-transfusion unit through a fourth blood transfusion tube; the fineseparation unit is further connected with the storage unit through a discharge pipe; the fine separation unit is used for extracting the circulating tumor cells from the components containing the circulating tumor cells; the storage unit is used for storing the components containing the circulating tumor cells and / or the circulating tumor cells; a control unit is separately connected with the blood collection unit, the primary separation unit, the fine separation unit, and the reverse-transfusion unit. The device disclosed by the invention has one beneficial effect that the circulating tumorcells in the whole body can be removed by filtration.

Description

technical field [0001] The invention relates to the field of medical devices, and more specifically, the invention relates to an in vivo closed-loop extraction device for circulating tumor cells. Background technique [0002] Circulating tumor cells (circulating tumor cells), also referred to as CTC. Circulating tumor cells are a general term for all kinds of tumor cells existing in peripheral blood. Due to spontaneous or therapeutic operation, they fall off from solid tumor lesions (primary tumors, metastases), and most of them undergo apoptosis or death after entering peripheral blood. After being swallowed, a small number can escape and develop into metastases, increasing the risk of death in patients with malignant tumors. It can be seen that circulating tumor cells are closely related to the recurrence and metastasis of malignant tumor cells. [0003] Nowadays, medical technology is constantly developing and innovating. In order to further realize in-depth research on...

AI Technical Summary

Problems solved by technology

In fact, this method of extracorporeal treatment usually only draws a small amount of blood (about 10ml), and because the number of circulating tumor cells in peripheral blood is usually relatively small, it generally requires about hundreds of millions of white blood cells and hundreds of millions of white blood cells. Looking for a small number of circulating tumor cells among the 100 million red blood cells may produce a small part of the blood drawn (about 10ml) without circulating tumor cells, resulting in false negatives

Or, the circulating tumor cell content in a small part of blood (about 10ml) is extremely low, for example: only one or a few circulating tumor cells, then based on a series of reasons such as detection sensitivity, false negatives may also be caused Case

It can be seen that the existing in vitro detection of circulating tumor cells is likely to cause inaccurate final results, making it difficult to formulate a suitable treatment plan

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