Digital micro-flow control device for achieving high-throughput sorting of particles through sound surface wave technology

Abstract

The invention discloses a digital micro-flow control device for achieving high-throughput sorting of particles through a sound surface wave technology. The device comprises an upper pole plate and a lower pole plate, the lower pole plate is composed of a substrate, a piezoelectric layer, an electrode layer, a medium layer and a hydrophobic layer which are arranged in sequence, and the electrode layer comprises two symmetrically-arranged liquid storage tank areas, a precise droplet generation area and a sound surface wave gathering area. By means of the device, pretreatment operation of multiple biological experiments can be conducted and mainly comprises sorting and gathering. By applying voltage to a first electrode, a second electrode, an interdigital electrode and a third electrode according to a certain sequence and rule, an intermittent simulation flow channel for liquid is formed, so that the liquid flows in the required direction; based on the inverse piezoelectric effect, by controlling the voltage of the interdigital electrode, the proportion of acoustic force to viscous force is controllably changed, particles different in size can be subjected to corresponding separationoperation, and accordingly the high sorting efficiency can be obtained at high throughput.

Description

technical field [0001] The invention belongs to the technical field of microfluidic chips, and relates to a method for sorting and enriching micron-sized particles, in particular to a digital microfluidic device that utilizes surface acoustic wave technology to realize high-throughput sorting and enrichment of particles. Background technique [0002] Existing microfluidic technologies are divided into two categories: continuous-flow microfluidic-based microfluidic devices and droplet-based digital microfluidic (digital microfluidic: DMF) devices. The continuous microchannel device was first developed due to the simple processing technology. This device is characterized by one or more pipelines filled with fluid, and the samples in the pipeline are operated under the action of pressure field, electric field or sound field. The advantages of simple technology and high throughput. For example: In 2015, researchers at the University of Pennsylvania in the United States used sur...

AI Technical Summary

Problems solved by technology

At present, the operation of particle separation and enrichment mainly relies on the DEP effect, which has low efficiency and complicated device design and operation.

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