A kind of composite support and preparation method thereof

Abstract

The invention discloses a composite support and a preparation method thereof. The composite support is composed of a silk fibroin three-dimensional microporous support and hydroxyapatite, and the hydroxyapatite is evenly deposited on the surface of the silk fibroin support. The preparation method of the composite scaffold comprises the following steps: (1) preparing a silk fibroin three-dimensional microporous scaffold; (2) preparing a silk fibroin / hydroxyapatite composite scaffold by a microwave-assisted alternate mineralization method. The preparation method of the present invention adopts microwave-assisted technology, shortens the mineralization time, improves the mineralization efficiency, and prepares a composite scaffold material with excellent performance; the preparation method of the present invention also reduces the amount of mineralization solution, reduces the production cost; at the same time, the preparation method of the present invention does not use harmful organic solvents in the mineralization process to prevent environmental pollution; not only that, the preparation method of the present invention is simple to operate, and is convenient for large-scale industrial production.

Description

technical field [0001] The invention relates to the field of biological material preparation, in particular to a composite scaffold and a preparation method thereof. Background technique [0002] Bone is an important organ of the human body. Bone defects caused by trauma, disease or congenital osteogenesis imperfecta seriously affect human health. So far, more than 4 million bone defect operations each year require bone grafting or bone substitutes for repair. However, the source of bone grafting is limited, and it is prone to postoperative infection and various complications, seriously affecting the quality of life of patients. With the continuous development of the field of biomedical materials, various metals, metal alloys, and ceramic stents are widely used in actual treatment, but these materials have general biocompatibility and insufficient mechanical properties, and cannot be implanted into the human body. Satisfactory treatment effect. Therefore, in recent years, ...

AI Technical Summary

Problems solved by technology

The reaction process of preparing composite scaffold materials by direct mixing is complicated and difficult to mix evenly, which seriously affects the forming quality of composite scaffolds; while traditional biomimetic mineralization mainly undergoes mineralization reactions through repeated long-term soaking processes, although composite scaffolds with excellent performance can be prepared. Scaffold material, but its reaction cycle is long, the synthesis efficiency is low, it cannot be used for large-scale preparation and production, and it cannot meet the needs of the market

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