Artificial saliva for oral complications of head and neck neoplasm radiotherapy patients

Abstract

The invention belongs to the technical field of medicines and particularly relates to artificial saliva for oral complications of head and neck neoplasm radiotherapy patients. The artificial saliva is prepared from raw materials including NaCl, KCl, CaCl2.2H2O, NaHPO4.2H2O, Na2S.2H2O, Urea and distilled water are taken as raw materials and designed in a reasonable ratio, so that components of the artificial saliva are close to those of real saliva of human oral cavities, and the artificial saliva has characteristics of good taste, no irritation and significant curative effect, and has good treatment and prevention effects on clinical common complications such as radioactive xerostomia, mucositis, ulcer, decayed tooth, gingivitis, periodontal disease, alveolar abscess and taste declination caused by head and neck neoplasm radiotherapy.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to an artificial saliva used for oral complications of head and neck tumor radiotherapy patients. Background technique [0002] Head and neck tumors (nasopharyngeal carcinoma, oral cavity cancer, and laryngeal cancer, etc.) are one of the common clinical malignant tumors, and radiotherapy plays an important role in the treatment of head and neck tumors; since head and neck tumors are mostly adjacent to normal oral tissues, radiotherapy is inevitable Cause different degrees of radiation damage to oral salivary glands and mucosal epithelial cells, resulting in decreased saliva secretion, decreased PH value, and bacterial flora imbalance, resulting in radiation xerostomia, mucositis, ulcers, dental caries, gingivitis, periodontal disease, alveolar abscess, taste Common clinical complications such as decreased radiotherapy seriously affect the effect of radiotherapy and the quality of ...

AI Technical Summary

Problems solved by technology

[0002] Head and neck tumors (nasopharyngeal carcinoma, oral cavity cancer, and laryngeal cancer, etc.) are one of the common clinical malignant tumors, and radiotherapy plays an important role in the treatment of head and neck tumors; since head and neck tumors are mostly adjacent to normal oral tissues, radiotherapy is inevitable Cause different degrees of radiation damage to oral salivary glands and mucosal epithelial cells, resulting in decreased saliva secretion, decreased PH value, and bacterial flora imbalance, resulting in radiation xerostomia, mucositis, ulcers, dental caries, gingivitis, periodontal disease, alveolar abscess, taste Common clinical complications such as decreased radiotherapy seriously affect the effect of radiotherapy and the quality of life of patients; at present, due to the lack of specific drugs for oral radiotherapy complications, and the symptomatic treatment effect is not good; for example, M choline receptor agonists represented by pilocarpine, Although it can improve symptoms, it needs long-term medication and may cause systemic adverse reactions. Artificial saliva has been used for many years to treat dry mouth. The cycle of relieving dry mouth symptoms is long, the antibacterial effect is not ideal, and it is easy to be lost; such as the artificial saliva disclosed in the patent CN1130066A, which is prepared by mixing various inorganic salts, preservatives and sterile distilled water, but its existence time Short, poor taste, easy to lose and other problems; Another example is the artificial saliva disclosed in patent CN105147818A, its main components are chitosan and grapefruit seed extract prepared with water for injection or purified water as the carrier, the artificial saliva is suitable for surrounding Relief of xerostomia during surgery, tumors, radiotherapy and chemotherapy patients, treatment and prevention of complications caused by xerostomia, and treatment of refractory oral ulcers caused by imbalance of oral flora due to low immunity, but the treatment cycle is long and the curative effect needs to be further improved; Therefore, there is an urgent need for a kind of artificial saliva aimed at the mechanism of radiotherapy oral complications, with stable efficacy and definite curative effect.

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