An afterload device for perfusion of isolated hearts
An afterload and heart technology, applied in the field of biomedical engineering, can solve problems affecting the quality of perfusion and heart function
Active Publication Date: 2020-09-01
SHANGHAI UNIV
View PDF5 Cites 0 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
In the isolated perfusion system, the blood vessels are replaced by medical tubing. When the blood is pumped out, it flows back to the heart without encountering any resistance. This is significantly different from the actual physiological conditions in the body. The degree of afterload of the heart will vary. Directly affect the function of the heart and affect the quality of perfusion
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Embodiment Construction
[0026] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.
[0027] The object of the present invention is to provide an afterload device for isolated heart perfusion to solve the above-mentioned problems in the prior art, which can provide the resistance encountered when the blood is pumped out, and simulate the normal working mode of the heart in the body.
[0028] In order to make the above objects, features and advantages of the present invention more comprehensible, the present invention will be further described in...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
Login to View More Abstract
The invention discloses an afterload device for isolated heart perfusion, which comprises an afterload energy storage module, an air pressure adjustment module and two flow rate regulators, which are connected through pipelines. The post-load energy storage module includes a rigid airtight container and a flexible container. The perfusate flows in from one side of the flexible container through the pipeline, and the flexible container is subjected to the pressure of the medium in the rigid airtight container, and the perfusate flows out from the other side. The pressure regulating module includes two pressure regulating valves and a compressible medium source, and regulates the pressure range in the rigid airtight container to always keep between the set diastolic pressure and the set systolic pressure. Through pressure, the liquid in the flexible container is squeezed to provide afterload in the perfusion of the isolated heart, making it more in line with physiological conditions and improving the perfusion quality.
Description
technical field [0001] The invention relates to the technical field of biomedical engineering, in particular to an afterload device for isolated heart perfusion. Background technique [0002] Isolated heart perfusion (ESHP) is an effective method that can facilitate donor heart preservation and functional assessment. Using this technique not only enables ex vivo evaluation of dysfunctional donor hearts, but also enables ex vivo repair of poorer quality hearts to alter their properties, thereby expanding the donor pool. [0003] Perfusion of the isolated heart was first proposed by Oscar Langendorff in the late 19th century. In the traditional Langendorff perfusion mode, the perfusion fluid is reversely perfused through the cardiac aortic cannula. Due to the effect of the perfusion hydraulic pressure, the aortic valve is closed and the perfusion fluid flows into the coronary artery. The heart provides the oxygen and energy that keep the heart beating for hours. [0004] Thi...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More Patent Type & Authority Patents(China)
IPC IPC(8): A01N1/02
CPCA01N1/0247A01N1/0273
Inventor 彭艳徐志兵辛立明罗均谢少荣蒲华燕高守玮米特什·巴迪瓦拉孙钰
Owner SHANGHAI UNIV