Microcapsule manufacturing system driven by machinery to generate high pressure

Abstract

The invention provides a microcapsule manufacturing system driven by machinery to generate high pressure, and belongs to the technical field of micro-nano manufacturing. The system comprises a mechanical energy input device, a friction nano-generator, a rectifying / boosting circuit and a microcapsule generator which are connected in sequence, wherein the mechanical energy input device drives the friction nano-generator to generate kV-level voltage and mA-level current, and the generated voltage is adjusted to be stable kV-level voltage after passing through the rectifying / boosting circuit and input into the microcapsule generator. According to the microcapsule manufacturing system driven by the machinery to generate the high pressure, the friction nano-generator and biological microcapsulemanufacturing are combined, and a high-voltage electrostatic field is generated through mechanical motion friction, so that the diameters of droplets ejected by a needle are greatly reduced; while thefriction nano-generator generates high voltage, the current in the circuit is very small, so that the system is very safe for operators and does not threaten biological cells, thereby providing a safe, controllable, concise and low-cost manufacturing platform for biological microcapsules.

Description

technical field [0001] The invention belongs to the technical field of micro-nano manufacturing, and in particular relates to a microcapsule manufacturing system based on mechanical drive to generate high pressure. Background technique [0002] Cell microcapsule technology is a technology that wraps cells with biocompatible semipermeable membranes to form microcapsules, and further cultures cells on this basis. The biocompatible semipermeable membrane can allow small molecules such as electrolytes, nutrients and oxygen to pass through to support the life activities of cells, and some small molecule biomass and cell metabolites can also be excluded from cells through the semipermeable membrane. Harmful macromolecules cannot pass through the semipermeable membrane. Cell microcapsule technology can achieve three-dimensional cell culture and directional release of drugs, so it has a wide range of applications in cell transplantation and medicine, and is listed as one of the key...

AI Technical Summary

Problems solved by technology

Therefore, it is impossible to obtain microcapsules with a diameter of micrometers without applying external force

At present, the existing microcapsule production system can be divided into two categories according to the working principle. One is the air fluid microcapsule production system, represented by Nisco company in Switzerland. The main principle is to use the air flow with a certain speed to cut liquid to form microspheres. The problem of this type of microcapsule production system is that the diameter of the capsule is relatively large (generally greater than 400 microns) and the size uniformity is poor, which affects the use effect of the microcapsule to a certain extent; Patent CN201735389U discloses a new device for forming microcapsules and a high-voltage electrostatic field generator. Its principle is to use commercial power to generate high voltage, and use electrostatic force to drive the liquid to overcome surface tension and viscous force, and the capsules are formed uniformly and stably. The microcapsule-like generator has the problems of uncontrollable current, easy to kill cells and high cost

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