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Composition containing amide derivative and its application in cosmetics

An amide derivative and composition technology, applied to the composition and its application field in cosmetics, can solve the problems of low toxicity and irritation, toxicity and irritation, etc., to increase the skin, reduce the darkening of the skin, and inhibit the skin melanin calm effect

Active Publication Date: 2019-10-18
广州双慧化妆品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Various skin care compositions and regimens have been widely developed in recent years, however, some active ingredients exhibit side effects such as toxicity and irritation while exhibiting skin lightening, therefore, there is an urgent need to develop Composition with excellent effect on the skin

Method used

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  • Composition containing amide derivative and its application in cosmetics
  • Composition containing amide derivative and its application in cosmetics
  • Composition containing amide derivative and its application in cosmetics

Examples

Experimental program
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Effect test

Embodiment 1

[0052] Example 1: Compositions comprising amide derivatives Formulation 1:

[0053] This embodiment provides a composition comprising amide derivatives, comprising:

[0054] a. the amide derivative (A) shown in formula (1a);

[0055]

[0056] b. Resorcinol derivatives (B) shown in formula (2a);

[0057]

[0058] c. At least one cosmetically acceptable component (C).

[0059] [ 3.1.0] -Hexane-3-carboxamide.

[0060] The combination of the composition comprising the amide derivative (A) represented by the formula (1) and the resorcinol derivative (B) represented by the formula (2) of the present invention has a positive effect on the skin. The derivatives have a positive enhancement effect on the transdermal delivery of the composition, which is beneficial for the active substance of the composition to penetrate through each layer of skin to reach the action site; inhibit skin melanin, prevent, brighten or alleviate skin melanin, skin aging or other Discontinuous visibl...

Embodiment 2～6

[0073] Examples 2-6: Compositions containing amide derivatives Formulations 2-6:

[0074] Examples 2-6 respectively provide the following composition formulations containing amide derivatives with formulations 2-6, the specific components of which are shown in Table 1.

[0075] Table 1, composition formula 2~6

[0076]

[0077]

experiment example 1

[0088] Experimental Example 1: Skin Permeability Diffusion Experiment:

[0089] Skin penetration studies were performed on the compositions in Examples 1-6 and Comparative Examples 7-17 above using a Franz diffusion cell maintained at 37°C during the experiment. The receptor medium is phosphate buffered saline at pH 7.4, the receptor volume is 12 mL and the osmotic area is 1.77 cm 2 . Hairless full-thickness porcine skin (approximately 1.5 mm) was used and all assays were performed in triplicate. 400 [mu]L of each preparation was placed at the donor site of the skin diffusion cell and the experiment was initiated by continuously mixing the acceptor medium. Collect acceptor phase samples at 1, 12, 24 and 48h, use HPLC [Waters C18XBridge, 3.5 μ m, 4.6mm × 150mm, mobile phase is 20mM potassium phosphate buffer (pH4.4): acetonitrile (80:20), flow rate 1 mL / min, injection volume 10 μL, detection at 216 nm, column temperature 40° C., running time 10 min] to measure the permeabili...

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Abstract

The invention relates to the field of cosmetics, and especially relates to a composition comprising an amide derivative and its use in cosmetics. The composition comprises: a. at least one amide derivative (A) represented by a formula (1); b. at least one resorcinol derivative (B) represented by a formula (2); and c. at least one cosmetically acceptable component (C). The amide derivative contained in the composition described in the present application has a positive reinforcing effect on the transdermal delivery of the composition, which facilitates the active substance of the composition toreach an action site through the skin of each layer, the composition prevents and / or inhibits changes in the appearance of discontinuities visible to the skin caused by melanin pigmentation, skin aging or other conditions, and is capable of treating, regulating or preventing oxidative stress or degradation of the skin, the composition also inhibits melanin generation and precipitation, reduces skin color and whitens the skin color, and keeps skin clear and white.

Description

technical field [0001] The present invention relates to the field of cosmetics, in particular to a composition comprising amide derivatives and its application in cosmetics, Background technique [0002] The skin covers the surface of the human body and is in direct contact with the external environment. It has functions such as protection, sensation, secretion, excretion, and respiration. The skin is tightly combined with the epidermis and dermis. The epidermis is composed of stratified squamous epithelium, which is stratum corneum, clear layer, granular layer and germinal layer from shallow to deep. The stratum corneum is composed of multi-layered keratinized epithelial cells (nuclei and organelles disappear, and the cell membrane is thicker), lifeless, lifeless Water-permeable, with the functions of preventing the outflow of tissue fluid, anti-friction and anti-infection. The cells of the germinal layer proliferate continuously and gradually migrate outward to replenish ...

Claims

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Application Information

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IPC IPC(8): A61K8/49A61Q19/02A61Q19/08A61P17/00A61P17/18A61P39/06
CPCA61K8/492A61K8/4966A61Q19/02A61Q19/08A61P17/00A61P17/18A61P39/06A61K2800/592
Inventor 刘海舟
Owner 广州双慧化妆品有限公司
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