Single-layer microfluidic chip with three-dimensional focusing function

A microfluidic chip, single-layer technology, applied in laboratory utensils, laboratory containers, chemical instruments and methods, etc., can solve the problems of reduced analysis and sorting accuracy, flow channel congestion, complex structure, etc. Improve analysis or sorting accuracy, prevent flow channel blockage, and achieve the effect of three-dimensional focusing
CN110339877APending Publication Date: 2019-10-18SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI +1

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
Publication Date
2019-10-18

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Abstract

The invention discloses a single-layer microfluidic chip with three-dimensional focusing function. The single-layer microfluidic chip comprises a single-layer microfluidic chip main body, and a main runner and a focusing module that are arranged disposed in the single-layer microfluidic chip main body. The focusing module includes a sample pipeline communicated with the main runner, a first sheathliquid pipeline and a second sheath liquid pipeline that are communicated with the main runner to realize focusing of a sample flow in the main runner in a vertical direction, and a third sheath liquid pipeline and a fourth sheath liquid pipeline that are communicated with the main runner to realize focusing of the sample flow in the main runner in a horizontal direction. By means of the sheath liquid in the first sheath liquid pipeline and the second sheath liquid pipeline, the single-layer microfluidic chip provided by the invention realizes focusing of the sample flow in the XZ plane, andthrough the third sheath liquid pipeline and the fourth sheath liquid pipeline, focusing in the XY plane can be realized, thereby realizing three-dimensional focusing. The single-layer microfluidic chip enables single-row flow of the sample in the main runner, not only improves the precision of analysis and sorting, but also has a simple structure and is low in cost.
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Description

technical field

[0001] The invention relates to the field of microfluidic chips, in particular to a single-layer microfluidic chip with a three-dimensional focusing function. Background technique

[0002] The development of modern life science is inseparable from the innovation and progress of research methods, especially the development of separation, analysis and testing methods for micron or submicron particles, which has greatly promoted the development of modern life science to a higher, deeper and more refined level. level development. Since 1990, when scientists first proposed a miniature total analysis system, microfluidic technology has gradually become an important development frontier in the current microscopic field of analysis. It can integrate the sample preparation, reaction and other operations of biological, chemical, and medical analysis processes into a single micron scale. On the chip, the whole process of analysis is automatically completed, which is ca...

Claims

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