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Multi-dimensional liquid chromatography separation system based on two-position six-way valve

A technology of multi-dimensional liquid chromatography and two-position six-way valve, which is applied in the field of multi-dimensional liquid chromatography separation system, can solve problems such as the complexity of chromatographic separation methods, and achieve the effect of simple and easy development

Pending Publication Date: 2019-10-18
李宜珊
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Problems solved by technology

However, the detector of this system is connected after the enrichment column array, and the enrichment column switching is not carried out under the real-time guidance of the chromatographic signal, and the establishment of the chromatographic separation method is relatively complicated

Method used

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  • Multi-dimensional liquid chromatography separation system based on two-position six-way valve
  • Multi-dimensional liquid chromatography separation system based on two-position six-way valve
  • Multi-dimensional liquid chromatography separation system based on two-position six-way valve

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Embodiment

[0040] Embodiment: A kind of structure of multidimensional liquid chromatography separation system

[0041] In this embodiment, the enrichment column array is composed of two-stage enrichment column arrays and operates according to the principle of one enrichment column array. Each enrichment column array has 9 enrichment columns, that is, the enrichment column array is 18 enrichment columns. , sequentially numbered as the first enrichment column of the enrichment column array, the second enrichment column, etc., and the last number is the 18th enrichment column of the enrichment column array; the liquid chromatography separation column array has 5 separation columns , sequentially numbered as the first separation column, the second separation column, etc., and the last one is the fifth separation column; the two-position six-way valve in Figure 8(a) is in state A, and the two-position six-way valve in Figure 8(b) The six-way valve is in the B state.

[0042] The following is...

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Abstract

The invention provides a multi-dimensional liquid chromatography separation system. The system comprises a high performance liquid chromatography gradient pump A, a high performance liquid chromatography gradient pump B, a high performance liquid dilution pump, a gradient mixer A, a gradient mixer B, a sample feeding valve, an enrichment column array, a fraction collector, a liquid chromatographyseparation column array, a detector, a two-position six-way valve and a connecting pipeline. A chromatography separation column of each dimension is selected through the liquid chromatography separation column array; multi-dimensional chromatography separation is monitored and controlled fully online through the same gradient eluting system and the same detector, so that cleaning level of the enrichment column and the separation column can be controlled. Separation of all dimensions are connected through enrichment columns, and the dilution pump is employed to aid enrichment and capture of compounds. Monomeric compounds hard to separate in a complex system sample can be separated efficiently by selecting different combinations of chromatographic stationary phases and mobile phases.

Description

technical field [0001] The invention belongs to the technical field of high performance liquid chromatography separation, and relates to a multidimensional liquid chromatography separation system. Background technique [0002] In order to perform automated, large-scale, and systematic separation and purification of complex samples with uneven content and unknown components, and quickly perform high-resolution, high-throughput qualitative and quantitative analysis of all components, a multi-dimensional chromatographic separation system and multi-dimensional separation method were established. very necessary. In addition, in order to achieve high-resolution separation of difficult-to-separate substances with similar physical and chemical properties such as isomers and structural analogs, it is also necessary to establish a cyclic multidimensional separation system and separation method. [0003] At present, the commonly used multidimensional liquid chromatography separation s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/10
CPCG01N30/02G01N30/10
Inventor 李宜珊
Owner 李宜珊
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