Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of a kind of palladium complex in fatty carbamylation reaction

A technology of fatty carbamoyl and fatty carbamoylation, which is applied to the application field of palladium complexes in fatty carbamylation reactions, and can solve the problems of mild reaction conditions, use of toxic reagents, and small adaptable range of substrates, etc. Achieve the effect of easy separation, high yield, low cost and low toxicity separation

Active Publication Date: 2022-04-05
SHANGHAI INST OF TECH
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, many of these methods have disadvantages such as the use of toxic reagents, mild reaction conditions, and limited scope of substrate adaptation.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of a kind of palladium complex in fatty carbamylation reaction
  • Application of a kind of palladium complex in fatty carbamylation reaction
  • Application of a kind of palladium complex in fatty carbamylation reaction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Synthesis of N,N-coordinated divalent palladium complexes Pd containing m-carborane ligands:

[0033]

[0034] At -78°C, n-BuLi (1.6M) in n-hexane (1.00 mL, 1.6 mmol) was slowly added dropwise to m-C containing ortho carborane 2 B 10 h 10 (92.0mg, 0.64mmol) in tetrahydrofuran solution, stirred at this temperature for 30 minutes, slowly rose to room temperature and continued to react for 1 hour, then added 3-chloromethylpyridine (162.3mg, 1.28mmol), continued to react at room temperature 5 hours. Then PdCl 2 (112.0 mg, 0.64 mmol) was added to the reaction system for an additional 2 hours. After the reaction is over, let it sit and filter, and dry the solvent under reduced pressure. The obtained crude product is separated by column chromatography (petroleum ether / ethyl acetate=8:1), and the brown target product palladium complex Pd (231.8 mg, produced rate of 72%).

[0035] 1 H NMR (400MHz, CDCl 3 ,25℃):δ=7.89(d,J=7.0Hz,2H),7.58(s,2H),7.42(d,J=6.5Hz,2H),7.30(t,...

Embodiment 2

[0038] Palladium complex catalyzed ethyl carbamylation reaction:

[0039]

[0040] The palladium complex Pd prepared in Example 1 was used as a catalyst to catalyze the formyl reaction of ethylamine: ethylamine (1mmol, 45mg) and divalent palladium complex Pd (0.01mmol, 5.0mg) were dissolved in 4mL of DMF, at 60 The reaction was carried out at ℃ for 10 hours. After the end, the concentrated reaction solution was directly separated by silica gel column chromatography, and dried until the mass remained unchanged to obtain the corresponding product C 3 h 7 NO (90% yield), 1 H NMR (400MHz, CDCl 3 , 25°C): δ=9.93 (s, 1H), 4.56 (s, 1H), 3.32-3.21 (m, 2H), 1.65 (t, J=7.5Hz, 3H). Elemental analysis: C 49.30, H9.65, N 19.16 (theoretical); C 49.33, H 9.68, N 19.19 (actual).

Embodiment 3

[0042] Palladium complexes catalyze the formylation of n-propylcarbamate:

[0043]

[0044]The palladium complex Pd prepared in Example 1 was used as a catalyst to catalyze the formyl reaction of n-propylamine: n-propylamine (1mmol, 59mg) and divalent palladium complex Pd (0.002mmol, 1.0mg) were dissolved in 4mL DMF, at 100 The reaction was carried out at ℃ for 8 hours, and after the end, the concentrated reaction solution was directly separated by silica gel column chromatography, dried until the mass remained constant, and the corresponding product C was obtained. 4 h 9 NO (96% yield), 1 H NMR (400MHz, CDCl 3 ,25℃):δ=9.95(s,1H),4.59(s,1H),3.36-3.25(m,2H),1.65-1.60(m,2H),1.09(t,J=7.2Hz,3H) . Elemental analysis: C 55.15, H 10.41, N 16.08 (theoretical); C 55.11, H 10.48, N 16.04 (actual).

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the application of a palladium complex in fatty carbamylation reaction, using N,N-coordinated palladium complex containing meta-carborane ligand as catalyst, and N,N-dimethyl Formamide is used as a formylating reagent and solvent to catalyze the formylation reaction of fatty amines to prepare fatty amine formamide compounds. Compared with the prior art, in the present invention, the divalent palladium complex containing meta-carborane ligands coordinated by N,N has higher catalytic activity under mild conditions, and can catalyze the formylation reaction of aliphatic amines , DMF is used as a formylating reagent and a solvent at the same time, it is cheap, low-toxic and easy to separate, and the yield is high (88‑96%).

Description

technical field [0001] The invention belongs to the technical field of synthetic chemistry and relates to the application of a palladium complex in fatty carbamylation reaction. Background technique [0002] Formamide widely exists in natural products and is often used as a pharmacodynamic functional group of drugs, and most of its derivatives have significant biological activity. In organic synthesis reactions, formyl is one of the most effective protecting groups for amino groups in amine compounds, and the formed formamide is also an important precursor for the synthesis of isocyanates and formamidines. In addition, formamide can also be used as a Lewis base catalyst to catalyze alkylation and hydrosilylation reactions. As early as the 1950s, Fieser et al. successfully used formic acid as a raw material to realize the formylation of aniline. Subsequently, various formylating reagents were reported correspondingly, such as chloral, ammonium formate, formate ester, etc. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): B01J31/18C07F15/00C07C231/08C07C233/03
CPCB01J31/1815C07F15/0066C07C231/08B01J2531/824B01J2531/0213C07C233/03
Inventor 姚子健吕文瑞李荣建高永红邓维
Owner SHANGHAI INST OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com