An experimental method of nicotinic acid applied to the treatment of cow mastitis through the gpr109a receptor

Abstract

The invention discloses an experimental method for an application of niacin in treating cow mastitis by using a GPR109A receptor. The experimental method comprises the steps of: S1, selecting cows with mastitis, wherein cows with positive mastitis are selected preliminarily, and a number of somatic cells of each cow is about 80-200 million / mL; S2, and detecting pro-inflammatory factors in cow serum and whey, wherein peripheral blood in normal cows, the cows with mastitis and niacin-fed cows with mastitis are collected on day 0 and day 7 respectively, and serum in the blood is extracted. The experimental method plans a whole new treatment strategy for cow mastitis, detects the expression of pro-inflammatory mediators in the cows with mastitis after niacin treatment by separating the serum and whey of the cows, comprehensively evaluates the therapeutic effect of niacin in treating cow mastitis by adopting the molecular biological method, and can achieve the effects of protecting mammaryglands and relieving inflammation since niacin can effectively reduce the expression of pro-inflammatory mediators in cow serum and whey.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an experimental method for treating dairy cow mastitis with niacin through a GPR109A receptor. Background technique [0002] Cow mastitis is an inflammatory disease caused by mixed infection of mammary gland tissue by various pathogenic microorganisms. All over the world, dairy cow mastitis is a serious problem that hinders the healthy development of the dairy industry. In recent decades, the problem of mastitis in dairy cows has not been well resolved and still causes huge economic losses to the dairy industry worldwide. The global economic loss caused by mastitis in dairy cows is as high as 35 billion U.S. dollars every year. The main cause of mastitis in dairy cows is the invasion of the mammary glands by pathogenic microorganisms. Although the application of antibiotics in dairy cows can kill pathogenic microorganisms, it has no good effect on some drug-resistant strains ...

AI Technical Summary

Problems solved by technology

Therefore, nicotinic acid, as a new type of anti-mastitis drug, has advantages that traditional medicines do not have, but the effect of nicotinic acid on mastitis is still unclear, so the present invention intends to use nicotinic acid to treat and prevent dairy cow mastitis

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