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Experimental method for application of niacin in treating cow mastitis by using GPR109A receptor

An experimental method, mastitis technology, applied in the field of medicine, can solve problems such as the unclear effect of nicotinic acid mastitis, achieve the effect of reducing the occurrence of mastitis, benefiting the treatment and prevention, and protecting the mammary glands

Active Publication Date: 2019-10-25
JILIN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, nicotinic acid, as a new type of anti-mastitis drug, has advantages that traditional medicines do not have, but the effect of nicotinic acid on mastitis is still unclear, so the present invention intends to use nicotinic acid to treat and prevent dairy cow mastitis

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  • Experimental method for application of niacin in treating cow mastitis by using GPR109A receptor
  • Experimental method for application of niacin in treating cow mastitis by using GPR109A receptor
  • Experimental method for application of niacin in treating cow mastitis by using GPR109A receptor

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Embodiment Construction

[0041] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0042] The present invention provides an experimental method for applying nicotinic acid to treat cow mastitis through GPR109A receptor, comprising the following steps:

[0043] S1. Screening of cows with mastitis: Preliminary screening of cows positive for mastitis, the number of somatic cells is about 800,000-2 million / mL;

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Abstract

The invention discloses an experimental method for an application of niacin in treating cow mastitis by using a GPR109A receptor. The experimental method comprises the steps of: S1, selecting cows with mastitis, wherein cows with positive mastitis are selected preliminarily, and a number of somatic cells of each cow is about 80-200 million / mL; S2, and detecting pro-inflammatory factors in cow serum and whey, wherein peripheral blood in normal cows, the cows with mastitis and niacin-fed cows with mastitis are collected on day 0 and day 7 respectively, and serum in the blood is extracted. The experimental method plans a whole new treatment strategy for cow mastitis, detects the expression of pro-inflammatory mediators in the cows with mastitis after niacin treatment by separating the serum and whey of the cows, comprehensively evaluates the therapeutic effect of niacin in treating cow mastitis by adopting the molecular biological method, and can achieve the effects of protecting mammaryglands and relieving inflammation since niacin can effectively reduce the expression of pro-inflammatory mediators in cow serum and whey.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an experimental method for treating dairy cow mastitis with niacin through a GPR109A receptor. Background technique [0002] Cow mastitis is an inflammatory disease caused by mixed infection of mammary gland tissue by various pathogenic microorganisms. All over the world, dairy cow mastitis is a serious problem that hinders the healthy development of the dairy industry. In recent decades, the problem of mastitis in dairy cows has not been well resolved and still causes huge economic losses to the dairy industry worldwide. The global economic loss caused by mastitis in dairy cows is as high as 35 billion U.S. dollars every year. The main cause of mastitis in dairy cows is the invasion of the mammary glands by pathogenic microorganisms. Although the application of antibiotics in dairy cows can kill pathogenic microorganisms, it has no good effect on some drug-resistant strains ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/50G01N21/64C12Q1/6876
CPCC12Q1/6876C12Q2600/158G01N21/6486G01N33/5023
Inventor 柳巨雄郭文晋付守鹏曹宇阚兴池
Owner JILIN UNIV
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