Magnetic particle imaging three-dimensional reconstruction method, system and device based on field free point (FFL)

Abstract

The invention belongs to the field of magnetic particle imaging and particularly relates to a magnetic particle imaging three-dimensional reconstruction method, system and device based on a field freepoint (FFL). The magnetic particle imaging three-dimensional reconstruction method, system and device based on the FFL aim at solving the problem of low accuracy of a magnetic particle distribution three-dimensional image based on the FFL. The magnetic particle imaging three-dimensional reconstruction method comprises the steps that current signal data of an induction coil in the three-dimensional scanning process of a scanned target based on the FFL are obtained; based on the current signal data, deconvolution is conducted through a preset kernel function, and thus a two-dimensional image data set is obtained; the kernel function is a jump function for increasing L2 regularized constraint; based on the two-dimensional image data set, an initial three-dimensional image is obtained througha Wiener filtering deconvolution algorithm; and based on the initial three-dimensional image, deconvolution is conducted through a Langevin function, and a final three-dimensional image is obtained through Radon transformation. The magnetic particle positioning accuracy in the reconstructed three-dimensional image is improved.

Description

technical field [0001] The invention belongs to the field of magnetic particle imaging, and in particular relates to a three-dimensional reconstruction method, system and device for magnetic particle imaging based on FFL. Background technique [0002] In clinical diagnosis and detection, how to accurately and objectively locate tumors and other lesions has always been an international research hotspot and challenging issue. Existing medical imaging technologies such as CT, MRI, SPECT and other methods all have problems such as high harm, poor positioning, and low precision. In recent years, a new tracer-based imaging method—magnetic particle imaging (MPI) has been proposed. Using tomographic imaging technology, MPI can accurately locate tumors or targets by detecting the spatial concentration distribution of superparamagnetic iron oxide nanoparticles (SPIOs) that are harmless to the human body. It has three-dimensional imaging, high temporal and spatial resolution and high ...

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Problems solved by technology

[0004] In order to solve the above problems in the prior art, that is, in order to solve the problem of low accuracy of the three-dimensional image of magnetic particle distribution based on FFL, the first aspect of the present invention proposes a three-dimensional reconstruction method for magnetic particle imaging based on FFL , the method includes the following steps:

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