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Joint normalization and difference detection method

A difference detection and normalization technology, applied in the field of bioinformatics, can solve problems such as the lack of efficient normalization methods for multiple data sets, achieve efficient and accurate normalization and difference detection, high degree of visualization, and eliminate localization. The effect of bias

Inactive Publication Date: 2019-11-08
HOHAI UNIV CHANGZHOU
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Problems solved by technology

In the current field of biological information, the normalization methods for data sets mainly focus on the normalization of a single data set, and there is a lack of efficient normalization methods for multiple data sets

Method used

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Embodiment Construction

[0021] The present invention will be further described below in conjunction with the accompanying drawings. The following examples are only used to illustrate the technical solution of the present invention more clearly, but not to limit the protection scope of the present invention.

[0022] Such as figure 1 As shown, a joint normalization and difference detection method includes the following steps:

[0023] Step 1): Comparison of preprocessing and visualization processes based on differences in high-throughput chromatin interaction datasets;

[0024] Step 2): A joint normalization process based on the high-throughput chromatin interaction data set that has been preprocessed for differential comparison;

[0025] Step 3): The process of difference detection and analysis based on the high-throughput chromatin interaction data set that has completed joint normalization.

[0026] The step 1) specifically refers to:

[0027] 1A) Use the high-throughput chromatin interaction d...

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Abstract

The invention discloses a joint normalization and difference detection method. The method comprises the steps that difference comparison preprocessing and visual processing are conducted on the basisof a high throughput chromatin interaction data set; joint normalization is conducted on the basis of the high throughput chromatin interaction data set obtained after difference comparison preprocessing is conducted; difference detection and analysis are conducted on the basis of the high throughput chromatin interaction data set completing joint normalization. The method has the advantages thatdifference comparison preprocessing and visual processing are creatively provided, and the blank of the normalization and difference detection method for multiple data sets at present is filled up; efficient accurate normalization and difference detection of multiple high throughput chromosome interaction data sets can be achieved; in addition, the technical method is relatively efficient and rapid and high in degree of visualization..

Description

technical field [0001] The invention relates to a combined normalization and difference detection method, which belongs to the technical field of bioinformatics. Background technique [0002] The chromatin interaction frequency IF (Interaction Frequency) in the 3D chromosome structure of the genome is a set of important data. It determines not only cell type and specific gene expression, but also the misregulation of oncogenes and tumor suppressors in cancer. Therefore, studying chromatin interactions is an essential step towards understanding genome regulation. The development of modern biology has evolved the traditional chromatin conformation capture (3C) technology into Hi-C sequencing technology, which allows us to detect long-distance chromatin interactions throughout the genome and also enables us to understand the impact of chromatin interactions The factors are more clearly understood, mainly divided into technology-specific bias and bias caused by DNA sequence. ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B30/00
CPCG16B30/00
Inventor 汤斌华王宇琦
Owner HOHAI UNIV CHANGZHOU