Preparation method of antibacterial dressing

A technology of antibacterial drugs and water-soluble polymers, which is applied in medical science, bandages, absorbent pads, etc., can solve the problems of uneven distribution of antibacterial drugs, uneven release of antibacterial drugs, and inability to achieve antibacterial effects, so as to prevent and treat wounds. Infection, wide range of use, and low cost effects

Inactive Publication Date: 2019-11-15
上海凌仕医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the finished product has the following problems: the antibacterial drugs cannot be evenly distributed on the surface of the dressing base material, especially the inner layer of the dressing base material, resulting in uneven release of the antibacterial drugs, and the ideal antibacterial effect cannot be achieved.

Method used

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  • Preparation method of antibacterial dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A kind of preparation method of antibacterial dressing, concrete steps are as follows:

[0026] 1. Dissolve 50 μg of antibiotics and 100 μg of PEG1000 polymer in 100 mL of dichloromethane solvent, stir and dissolve completely, and let stand at room temperature for 10 minutes to obtain a solution composition containing antibacterial drugs;

[0027] 2. Slowly place the 10×10cm hydrogel dressing in the solution composition containing antibacterial drugs, soak for 5 minutes, take it out and let it stand at room temperature for 30 minutes to obtain a hydrogel dressing containing antibiotics;

[0028] 3. Dissolve 200 μg of PEG1000 polymer in 13 mL of water, stir and dissolve completely, and let it stand at room temperature for 10 minutes to obtain a PEG1000 polymer solution. Use a brush to apply the PEG1000 polymer solution to the antibiotic-containing hydrogel dressing obtained in step 2. On the antibiotic drug coating, let stand at room temperature for 50 minutes;

[0029]...

Embodiment 2

[0031] A kind of preparation method of antibacterial dressing, concrete steps are as follows:

[0032] 1. Dissolve 1000 μg of sulfonamide and 50 μg of PEG1000 polymer in 10 mL of ethanol solvent, stir and dissolve completely, and let stand at room temperature for 10 minutes to obtain a pharmaceutical solution composition containing sulfonamide;

[0033] 2. Slowly place the 5×6cm foam dressing in the sulfa drug-containing solution composition, soak for 1 minute, take it out and let it stand at room temperature for 60 minutes, and obtain the sulfa drug-containing foam gel dressing;

[0034] 3. Dissolve 200 μg of PEG1000 polymer in 13 mL of water, stir and dissolve completely, and let stand at room temperature for 10 minutes to obtain a PEG1000 polymer solution. Use a brush to apply the PEG1000 polymer solution to the sulfa drug-containing foam gel dressing obtained in step 2. On the antibacterial drug coating, stand at room temperature for 100 minutes;

[0035] 4. Repeat steps ...

Embodiment 3

[0037] A kind of preparation method of antibacterial dressing, concrete steps are as follows:

[0038] 1. Dissolve 10 μg of miconazole and 50 μg of PEO polymer in 1000 mL of acetone solvent, stir and dissolve completely, and let stand at room temperature for 10 minutes to obtain a pharmaceutical solution composition containing miconazole;

[0039] 2. Apply the miconazole-containing drug solution composition to the surface of the 5×8 cm alginate dressing with a roller, roll it at least twice, and let it stand at room temperature for 60 minutes to obtain the miconazole-containing drug alginate dressing;

[0040] 3. Dissolve 5 μg of PVA polymer in 10 mL of water, stir and dissolve completely, and let it stand at room temperature for 10 minutes to obtain a PVA polymer solution. Use a brush to apply the PVA polymer solution to the miconazole-containing drug alginate obtained in step 2. On the miconazole drug coating of the dressing, let stand at room temperature for 10 minutes;

...

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Abstract

The invention discloses a preparation method of an antibacterial dressing, which solves the problem of the existing antibacterial drug dressing. The method comprises the specific steps: step 1, dissolving an antibacterial drug and a water-soluble polymer in an organic solvent to obtain a liquid antibacterial drug composition, applying the liquid antibacterial drug composition on the surface of a dressing body, and drying the material; step 2, coating the surface of the antibacterial drug coating of the dressing body with the liquid water-soluble polymer and drying the material to obtain the dressing body containing a water-soluble polymer coating layer and an antibacterial drug coating layer; and step 3, repeating steps 1 and 2 at least once to ensure that the antibacterial drug coating layer and the water-soluble polymer coating layer are superimposed separately and that the water-soluble polymer coating layer is always on the outermost side to obtain the finished product. The finished product of the invention can continuously, uniformly and stably release antibacterial drug to achieve an effective antibacterial effect. Therefore, the wound can be effectively controlled and infected, and the preparation method has simple steps, short time and low cost.

Description

technical field [0001] The invention relates to the field of wound care, in particular to a preparation method of an antibacterial dressing. Background technique [0002] Chronic and generalized wounds are the greatest challenge to health systems worldwide. These wounds are difficult to heal, time-consuming and can lead to serious complications including amputation of limbs and death. Elderly, diabetic, immunosuppressed, and immobile groups have increased rates of chronic wounds and other skin disorders resulting from poor circulation, immobility, eg, decubitus ulcers (decubitus ulcers), venous stasis ulcers, and diabetes. These chronic disease problems can greatly increase the cost of care and reduce the quality of life of patients. [0003] A wound can basically be defined as any intact break in the skin. Wounds are generally divided into acute and chronic. Acute wounds follow a normal healing process and generally take less than 8 weeks to heal. A chronic wound is a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/44A61L15/26A61L15/24A61L15/42A61L15/46
CPCA61L15/24A61L15/26A61L15/42A61L15/44A61L15/46A61L2300/404A61L2300/406A61L2300/602A61L2300/608A61L2420/02A61L2420/08C08L71/02C08L29/04
Inventor 陈振浪
Owner 上海凌仕医疗科技有限公司
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