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Combined drug for treating colorectal cancer

A technology for combined drug use and colorectal cancer, which can be applied to medical preparations containing active ingredients, antitumor drugs, drug combinations, etc., and can solve the problem of high mortality of colorectal cancer

Inactive Publication Date: 2019-11-19
JINZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the mortality rate of colorectal cancer is very high, mainly due to frequent postoperative metastasis and multi-drug resistance to chemotherapy drugs. Therefore, finding effective drugs for the treatment of colorectal cancer has become an urgent clinical problem. important question

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] A combination drug for treating colorectal cancer, which is composed of diosgenin, baicalin A, fucoidan and psoralen; the mass ratio of diosgenin, baicalin A, fucoidan and psoralen is 4 :1:0.5:2.

Embodiment 2

[0016] A combination drug for treating colorectal cancer, which is composed of diosgenin, baicalin A, fucoidan and psoralen; the mass ratio of diosgenin, baicalin A, fucoidan and psoralen is 4 :2:1:3.

Embodiment 3

[0018] A combination drug for treating colorectal cancer, which is composed of diosgenin, baicalin A, fucoidan and psoralen; the mass ratio of diosgenin, baicalin A, fucoidan and psoralen is 4 :1.5:0.75:2.5.

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PUM

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Abstract

The invention discloses a combined drug for treating colorectal cancer. The combined drug is prepared from diosgenin, baicalein A, fucoidan and psoralen. An in-vivo animal experiment shows that the combination application of the diosgenin, the baicalein A, the fucoidan, the psoralen, Binimetinib and cetuximab has a significant synergistic effect on the treatment of the colorectal cancer, the diosgenin can affect the blood supply of tumor by inhibiting the proliferation activity of endothelial cells, and finally inhibit the proliferation of a subcutaneous tumor model, meanwhile, the diosgenin can inhibit the metastasis of rectal cancer through the direct action, and has the synergistic interaction effect by combining with the cetuximab; and the purpose of tumor prevention can be achieved bythe psoralen through multiple mechanisms of calcium antagonistic effect, multi-drug resistance reversing effect, estrogen-like effect, photosensitive activity effect, apoptosis inducing , mitochondrial degeneration inducing and the like.

Description

technical field [0001] The invention relates to the field of medicaments, in particular to a combined medicine for treating colorectal cancer. Background technique [0002] Colorectal cancer (CRC) is one of the most common malignant tumors in the world, and its incidence rate accounts for the forefront of gastrointestinal tumors. The incidence of colorectal cancer in my country is increasing year by year. In addition, the mortality rate of colorectal cancer is very high, mainly due to frequent postoperative metastasis and multi-drug resistance to chemotherapy drugs. Therefore, finding effective drugs for the treatment of colorectal cancer has become an urgent clinical problem. important question. Contents of the invention [0003] In order to solve the above problems, the present invention provides a combined medicine for treating colorectal cancer. [0004] In order to achieve the above object, the technical scheme that the present invention takes is: [0005] A combin...

Claims

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Application Information

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IPC IPC(8): A61K31/58A61K31/352A61K31/715A61K31/37A61K39/395A61P35/00
CPCA61K31/58A61K31/352A61K31/715A61K31/37A61K39/395A61P35/00
Inventor 潘双任甫刘大华董永岩李垚李伟红王爱梅郭文娟
Owner JINZHOU MEDICAL UNIV