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Compound for treating vascular malformation

A vascular and malformation technology, applied in the field of compounds for the treatment of vascular malformations, can solve problems such as ineffective treatment of vascular malformations

Inactive Publication Date: 2019-11-26
THE FIFTH AFFILIATED HOSPITAL SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, there is no effective treatment for vascular malformations in the prior art

Method used

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  • Compound for treating vascular malformation
  • Compound for treating vascular malformation
  • Compound for treating vascular malformation

Examples

Experimental program
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Embodiment Construction

[0030] Application of CysLTR1 antagonist in preparation of medicine for treating vascular malformation.

[0031] In some instances, the vascular malformation is a vascular malformation caused by abnormal expression of DDX24.

[0032] In some examples, the vascular malformation includes portal vein stenosis, hepatic vein stenosis, pulmonary valve stenosis, chylothorax, portal hypertension, MOVLD syndrome, idiopathic noncirrhotic portal hypertension.

[0033] In some examples, the CysLTRl antagonist is selected from montelukast sodium, Zafirlukast, Cinalukast, Nedocromil, Pranlukast, and pharmaceutically acceptable derivatives thereof.

[0034] A method of treating vascular malformations comprising administering to a patient a therapeutically effective amount of a CysLTRl antagonist.

[0035] In some instances, the vascular malformation is a vascular malformation caused by abnormal expression of DDX24.

[0036] In some examples, the vascular malformation includes portal vein s...

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Abstract

The invention discloses a compound for treating vascular malformation. The inventor researches and discovers that a CysLTR1 antagonist can up-regulate expression in a vascular smooth muscle cell DDX24, and the CysLTR1 antagonist has a certain treating or improvement effect on the vascular malformation.

Description

technical field [0001] The present invention relates to a new application of the compound and a treatment method for diseases, in particular to a compound and a method for treating vascular malformation. Background technique [0002] The vascular system is mainly composed of blood vessels and lymphatic vessels, which undertake important physiological functions of the human body. Vascular disease refers to the abnormal proliferation, communication or morphological changes of the vascular system caused by various factors. Vascular diseases can occur in any tissue and part of the human body, and often exhibit aggressive or even malignant growth characteristics, which are extremely harmful to health. Vascular diseases that occur in the extremities, body surface or face can not only affect the appearance, but also form space occupying with irregular borders, oppress or invade adjacent tissues and organs, and lead to loss of normal physiological functions in severe cases. High-f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/47A61K31/404A61K31/426A61K31/4741A61K31/41A61P9/12A61P11/00A61P1/16A61P9/14
CPCA61K31/404A61K31/41A61K31/426A61K31/47A61K31/4741A61P1/16A61P9/12A61P9/14A61P11/00
Inventor 单鸿庞鹏飞毛军杰胡晓俊何欢欢肖非
Owner THE FIFTH AFFILIATED HOSPITAL SUN YAT SEN UNIV