Uses of WNK kinase inhibitors in prevention and/or treatment of pulmonary hypertension

A kinase inhibitor and pulmonary arterial hypertension technology, applied in the field of medicine, can solve problems such as the lack of a cure for pulmonary arterial hypertension, the uncurable mortality rate of pulmonary arterial hypertension, etc.
CN110585205AInactive Publication Date: 2019-12-20GENERAL HOSPITAL OF PLA
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
GENERAL HOSPITAL OF PLA
Publication Date
2019-12-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention discloses uses of WNK kinase inhibitors in prevention and / or treatment of pulmonary hypertension, and particularly uses of WNK 463 in the prevention and / or treatment of pulmonary hypertension and complications thereof. Experiments by inventors of the present application find that the WNK kinase inhibitors (especially the WNK 463) show relatively good effects on protection of pulmonic circulation-right-heart pressure and function, right ventricular hypertrophy, etc. of monocrotaline (MCT)-induced pulmonary hypertension in rats, and have potential value of being developedinto drugs for the prevention and treatment of pulmonary hypertension and complications thereof.
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Description

technical field

[0001] The present invention relates to the field of medical technology, in particular to the use of a WNK kinase inhibitor in the preparation of products for the prevention and / or treatment of pulmonary hypertension and its complications, especially the use of WNK463 in the preparation of products for the prevention and / or treatment of pulmonary hypertension and its complications use in the product. Background technique

[0002] Pulmonary arterial hypertension (PAH) refers to a hemodynamic and pathophysiological state in which the pulmonary artery pressure rises above a certain threshold. The etiology is complex and is caused by a variety of heart, lung or pulmonary vascular diseases. Failure can be an independent disease, a complication, or a syndrome. The diagnostic criteria of hemodynamics are: the average pulmonary artery pressure detected by right heart catheterization is ≥25mmHg at resting state at sea level.

[0003] Pulmonary hypertension is divide...

Claims

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