Bamboo fiber/hydroxyapatite/chitosan novel composite membrane and preparation method thereof

A technology of hydroxyapatite and bamboo fiber, which is used in medical science, tissue regeneration, prosthesis, etc. to accelerate bone growth, improve mechanical properties, and prevent infection.

Active Publication Date: 2019-12-20
HUNAN NORMAL UNIVERSITY
View PDF7 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the use of bamboo fiber for guiding bo

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Bamboo fiber/hydroxyapatite/chitosan novel composite membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1: Dissolve 1.5 g of chitosan in 80 ml of 2% glacial acetic acid to obtain a light yellow transparent mucus, add 0.3 g of nano-hydroxyapatite powder (average particle size is 30 nm) and add 20 ml of deionized water for ultrasonic After dispersing for 20 minutes, add dropwise to the chitosan solution under high-speed stirring, continue to stir at room temperature for 4 hours, add 1.0 g of surface carboxylated bamboo fibers (average length is 0.1 mm), ultrasonically disperse for 40 minutes, and continue to stir at room temperature. After stirring for 2 hours, it was left to defoam and cast on a glass plate to form a smooth dense film. The tensile strength of the composite film was 36 MPa, and the elongation at break was 25%. The film was soaked in simulated body fluid for 8 weeks, and the surface of the film was completely covered by bone-like apatite as observed by SEM; The tensile strength was 4 MPa, and the film began to lose strength by 12 weeks.

Embodiment 2

[0015] Example 2: Dissolve 1.5 g of chitosan in 60 ml of 2% glacial acetic acid to obtain light yellow transparent mucus, add 0.5 g of nano-hydroxyapatite powder (average particle size is 30 nm) and add 20 ml of deionized water for ultrasonic After dispersing for 30 minutes, add dropwise to the chitosan solution under high-speed stirring, continue to stir at room temperature for 4 hours, add 1.5 g of surface carboxylated bamboo fibers (average length is 0.1 mm), ultrasonically disperse for 1 hour, and continue to stir at room temperature. After stirring for 2.5 hours, it was left to defoam and cast on a glass plate to form a smooth dense film. The tensile strength of the composite film was 52 MPa, and the elongation at break was 28%. The film was immersed in simulated body fluid for 8 weeks, and its surface was completely covered by bone-like apatite as observed by SEM; the immersion continued until 10 weeks , the tensile strength of the film was 10 MPa, and the film began to ...

Embodiment 3

[0016] Example 3: Dissolve 1.2 g of chitosan in 50 ml of 2% glacial acetic acid to obtain light yellow transparent mucus, add 0.8 g of nano-hydroxyapatite powder (average particle size is 30 nm) and add 25 ml of deionized water for ultrasonic After dispersing for 30 minutes, add dropwise to the chitosan solution under high-speed stirring, continue to stir at room temperature for 4 hours, add 1.0 g of surface carboxylated bamboo fibers (average length is 0.1 mm), ultrasonically disperse for 1 hour, and continue to stir at room temperature. After stirring for 3 hours, it was left to defoam and cast on a glass plate to form a smooth dense film. The tensile strength of the composite film is 48 MPa, and the elongation at break is 26%. The film is immersed in simulated body fluid for 8 weeks, and its surface has been completely covered by bone-like apatite as observed by SEM; the immersion lasts until the immersion lasts for 10 weeks , the tensile strength of the film was 6 MPa, and...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Average lengthaaaaaaaaaa
Diameteraaaaaaaaaa
Tensile strengthaaaaaaaaaa
Login to view more

Abstract

The invention discloses a novel bamboo fiber/hydroxyapatite/chitosan composite membrane and a preparation method thereof. The composite membrane is prepared by the following steps: firstly, preparinga uniform composite liquid from nano-hydroxyapatite and chitosan, then adding surface-carboxylated natural bamboo fibers into the composite liquid, performing ultrasonic dispersing and uniform stirring, and then directly performing tape casting on a glass flat plate to form the novel composite membrane. The chitosan is subjected to ionic crosslinking by carboxyl on the surface of bamboo fibers, sothat the mechanical property and degradation property of the composite membrane are greatly improved compared with that of nano-hydroxyapatite/chitosan composite membranes. The novel composite membrane is rich in raw material source and simple in preparation method, the mechanical property, the degradation property, the bone conductivity and the antibacterial property of the composite membrane can be regulated and controlled through the component content of the composite membrane, and the composite membrane with excellent performance is expected to be obtained to be used for guiding bone tissue regeneration membranes.

Description

technical field [0001] The invention relates to a novel composite film of bamboo fiber / hydroxyapatite / chitosan and a preparation method thereof, belonging to the field of biomedical materials. Background technique [0002] In the treatment of periodontal disease, insufficient bone mass in dental implant areas, repair of other bone defects, and healing of fractures, it is a new method to place an ideal membrane on the defect as a mechanical barrier membrane. It can selectively separate the surrounding soft tissue, prevent epithelial cells and fibroblasts from growing to the defect, and at the same time create a special regeneration space under the membrane, so that bone-forming cells grow preferentially and generate new bone tissue , and then achieve the purpose of promoting bone healing. This membrane that can guide bone tissue regeneration is currently one of the research hotspots in the fields of dentistry and orthopedics. [0003] In the development of membrane materials...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61L27/36A61L27/20A61L27/12A61L27/50A61L27/58
CPCA61L27/12A61L27/20A61L27/3637A61L27/50A61L27/58A61L2430/02C08L5/08
Inventor 唐硕蒋柳云马兵利汤春燕苏胜培
Owner HUNAN NORMAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap