Angstrom silver, Angstrom silver gel for external use, preparation method and application

A gel and Amy technology, applied in the field of medicine, can solve problems such as slow wound healing, scarring, affecting the quality of life of patients and personal self-confidence

Active Publication Date: 2022-03-18
SHENZHEN AMCAN MEDICAL BIOTECH LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Infection due to factors such as lack of medical knowledge or improper care of patients leads to slow wound healing or even scars, which seriously affects the quality of life and personal confidence of patients

Method used

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  • Angstrom silver, Angstrom silver gel for external use, preparation method and application
  • Angstrom silver, Angstrom silver gel for external use, preparation method and application
  • Angstrom silver, Angstrom silver gel for external use, preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] A kind of angstrom silver of the present invention, its preparation method comprises the following steps:

[0053] (1) Fill the explosion chamber with inert gas argon to keep the air pressure in the explosion chamber at 1×10 6 Pa, and stabilize the working temperature at 8-12°C.

[0054] (2) Continuously push a silver wire with a diameter of 0.5mm and a length of 8-12cm into the explosion chamber. When the silver wire contacts the positive plate, a high voltage of 25kV is generated, causing the silver wire to explode and instantly evaporate the silver wire into silver. vapor plasma.

[0055] (3) The silver vapor accompanied by argon gas is pumped into the quenching chamber whose temperature is set at 0-4° C., and the silver vapor solidifies rapidly when it is cold and forms silver particles.

[0056] (4) The silver particles are dispersed by high-intensity ultrasonic waves (ultrasonic power is 15KW, frequency is 15KHz), and the dispersed silver particles are sucked to...

Embodiment 2

[0060] A kind of angstrom silver external use gel of the present invention, comprises 1.0g / L the angstrom grade elemental silver powder, the carbomer 934P of 9.8g / L, the triethanolamine of 5g / L, the high-purity bismuth of 984.2g / L distilled water.

[0061] Its preparation method comprises the following steps:

[0062] (1) Get the angstrom silver in Example 1 and add it in double-distilled water, use an ultrasonic oscillator to carry out dispersion treatment, control the ultrasonic power to 5KW, the frequency is 40KHz, and the dispersion time is 60s; the concentration obtained is 1.0g / L angstrom silver Dispersions.

[0063] (2) Add Carbomer 934P to the angstrom silver dispersion, and then use a magnetic rotor high-speed stirrer with a stirring speed of 2000 rpm to cut the angstrom silver solution until it is completely clarified to obtain a mixed solution. The concentration of Carbomer 934P in the mixed solution was 9.8g / L.

[0064] (3) Add triethanolamine to the mixed solut...

Embodiment 3

[0069] The application of the angstrom silver external gel of a kind of embodiment 2 in the preparation antibacterial preparation, its application method is:

[0070] (1) Grouping:

[0071] Blank group (Blank): double distilled water.

[0072] Empty gel group (Vehicle): including 9.8g / L carbomer 934P, 5g / L triethanolamine, and 984.2g / L double distilled water.

[0073] Nano silver gel group (AgNPs gel): Silki gel, which uses 1.0g / L nano-scale elemental silver powder.

[0074] Angstrom silver topical gel group ( gel): 1.0g / L angstrom level elemental silver powder, 9.8g / L carbomer 934P, 5g / L triethanolamine, 984.2g / L double distilled water.

[0075] (2) After the solutions of the above groups were made into gels, the circular paper pieces with a diameter of 6 mm were placed in each group of intervention agents and soaked for 12 hours. Place on the coated bacteria MH plate. Bacterial species: Streptococcus pyogenes (ATCC19615), Pseudomonas aeruginosa (ATCC 27853), Escherichi...

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Abstract

The invention discloses angstrom silver, angstrom silver gel for external use, a preparation method and application. Angstrom silver refers to silver particles with a particle size of 0-200 angstroms obtained by exploding silver vapor after contacting the silver wire with the positive electrode plate and quenching. The angstrom silver external gel includes angstrom silver, carbomer 934P, triethanolamine and double distilled water. Compared with nano silver, Angstrom silver has a smaller size and more obvious antibacterial effect. Angstrom silver gel for external use overcomes the shortcomings of simple silver particle agglomeration, and the gel shape enables Angstrom silver to stay in the lesion for a long-term and stable release of drugs. It has a strong broad-spectrum antibacterial ability and can be used to prepare broad-spectrum antibacterial and The drug for treating diabetic skin damage and burns has a remarkable effect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to angstrom silver, angstrom silver gel for external use, a preparation method and application thereof. Background technique [0002] With the acceleration of urbanization and aging process, people's lifestyles have changed, leading to an increase in the number of obese and overweight populations, and the incidence of diabetes in my country is increasing year by year. According to the 2017 edition of the "Guidelines for the Prevention and Treatment of Type 2 Diabetes in China", the incidence of diabetes in my country is 10.4%, and there are about 110 million diabetic patients. The occurrence of diabetic complications, such as diabetic skin damage, seriously affects the life expectancy and quality of life of patients, and increases the burden on families and society. Due to hyperglycemia and peripheral neurovascular lesions, diabetic patients slow down the repair of skin damage and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/14A61K9/06A61K47/32A61K47/18A61K33/38A61P31/04A61P17/02
CPCB22F9/14A61K9/06A61K47/32A61K47/18A61K33/38A61P31/04A61P17/02
Inventor 谢辉司徒伟怡殷豪陈春媛王杨
Owner SHENZHEN AMCAN MEDICAL BIOTECH LTD
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