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Metabolic marker of glioblastoma in urine and its use in early diagnosis

A technology for early diagnosis of glioblastoma, applied in the biological field, can solve the problems of strong invasiveness, insidious onset of glioma, and poor surgical treatment effect.

Active Publication Date: 2019-12-31
BEIJING TIANTAN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the onset of glioma is insidious and lacks specific early symptoms, which leads to the fact that the tumor is often discovered in the later stage of the tumor course. At this time, the tumor is large and invasive, and the effect of surgical treatment is often poor.

Method used

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  • Metabolic marker of glioblastoma in urine and its use in early diagnosis
  • Metabolic marker of glioblastoma in urine and its use in early diagnosis
  • Metabolic marker of glioblastoma in urine and its use in early diagnosis

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Embodiment Construction

[0053] Below in conjunction with accompanying drawing, further illustrate the present invention through the embodiment, but not as limitation to the present invention. Specific materials and their sources used in embodiments of the invention are provided below. However, it should be understood that these are merely exemplary and not intended to limit the present invention, and materials identical or similar to the type, model, quality, property or function of the following reagents and instruments can be used to implement the present invention. The experimental methods used in the following examples are conventional methods unless otherwise specified. The materials and reagents used in the following examples can be obtained from commercial sources unless otherwise specified.

[0054] We detected metabolites in urine by liquid chromatography-high resolution mass spectrometry (LC-MS) in full-scan mode, and screened metabolites associated with glioblastoma by multivariate statisti...

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Abstract

The invention relates to a metabolic marker of glioblastoma in urine and its use in early diagnosis. Specifically, the invention relates to the use of an agent for measuring the level of metabolites in the urine of a subject for preparing a kit or chip for diagnosing glioblastoma, wherein the metabolites in the urine are selected from one or more of the following: deoxycholate glycine conjugate, tyramine-oxy-sulfate, testosterone glucuronide, chenodeoxycholate sulfate, 2-hydroxy-ethyl sebate, and glycine chenodeoxycholate-3-glucuronide.

Description

technical field [0001] The invention relates to the field of biotechnology, more specifically to metabolic markers of glioblastoma in urine and its application in early diagnosis. Background technique [0002] According to the latest yearbook of the Ministry of Health in 2013, more than 300,000 patients die of brain tumors in my country every year. Glioblastoma is the most common primary malignancy of the brain, accounting for 47.6% of all primary brain malignancies (2018 US Brain Tumor Registry Report, CBTRUS) See, Q.T.Ostrom, H.Gittleman, G .Truitt, A.Boscia, C.Kruchko, J.S.Barnholtz-Sloan, CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2011-2015.Neuro Oncol 20(2018)iv1-iv86, the most malignant (WHO classification is grade IV with the highest degree of malignancy), and the treatment effect is poor. After standard surgery, radiotherapy and chemotherapy, the median survival period of patients is only 14.6 ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/88G01N30/89
CPCG01N30/88G01N30/89G01N2030/8809
Inventor 张扬季楠张力伟王燚李春朝
Owner BEIJING TIANTAN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV