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An improved traditional Chinese medicine composition of Jichuan decoction and its preparation method and application

A technology of composition and pharmaceutical preparation, which is applied in the field of improving the traditional Chinese medicine composition of Jichuanjian and its preparation, which can solve the problems of various types of medicines, large dosage of medicines, and high recurrence rate, and achieve no adverse reactions, low recurrence rate, and effective results. fast effect

Active Publication Date: 2021-10-08
九华华源药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chinese patent document CN105617284A discloses a pharmaceutical composition for treating habitual intractable constipation. The active ingredients of the traditional Chinese medicine are prepared from the following raw materials: 40 parts of Herba Cistanche, 40 parts of Acorus calamus, 40 parts of Semen Cassiae, 35 parts of Dandelion 35 parts of almonds, 35 parts of Alisma, 35 parts of mulberries, 30 parts of turmeric, 30 parts of Trichosanthes, 30 parts of Citrus aurantium, 28 parts of inulae root, 28 parts of burdock, 28 parts of Cortex Phellodendri, 25 parts of Atractylodes macrocephala , 25 parts of angelica, 25 parts of tangerine peel, 20 parts of polygala, 20 parts of myrrh, 20 parts of chuanxiong, 20 parts of poria cocos, 15 parts of licorice, 10 parts of yam, 10 parts of peach kernel; although it can be used to treat intractable constipation after clinical verification , but has the disadvantages of slow onset, low cure rate, high recurrence rate, large drug dosage, various types of drugs, and high cost.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Prepare Polygonum multiflorum 10g, peach kernel 5g, jujube 4g, Yu Liren 6g, Alisma 3g, Citrus aurantium 3g, Cimicifuga 3g.

[0028] Preparation method: (a) take Polygonum multiflorum multiflorum, peach kernel, jujube, Yu Liren, Alisma, Fructus Citrifolia and Cimicifuga according to the selected parts by weight, respectively pulverize and mix or mix and pulverize to obtain medicinal powder;

[0029] (b) Take the above-mentioned medicinal powder, add an appropriate amount of 50vt% ethanol for impregnation, and then use 75vt% ethanol as a solvent to percolate to obtain the percolation liquid of the traditional Chinese medicine composition;

[0030] (c) Take the percolating liquid of the above-mentioned traditional Chinese medicine composition, add conventional auxiliary materials and make clinically acceptable tablets according to conventional techniques.

Embodiment 2

[0032] Prepare Polygonum multiflorum 20g, peach kernel 10g, jujube 10g, Yu Liren 10g, Alisma 10g, Citrus aurantium 10g, Cimicifuga 10g.

[0033] Preparation method: (a) take Polygonum multiflorum multiflorum, peach kernel, jujube, Yu Liren, Alisma, Citrus aurantii and Cimicifuga according to the selected parts by weight, and grind them separately or mix them to obtain a medicinal powder;

[0034] (b) Take the above-mentioned medicinal powder, add conventional excipients and make clinically acceptable granules according to conventional techniques.

Embodiment 3

[0036] Prepare Polygonum multiflorum 15g, peach kernel 10g, jujube 8g, Yu Liren 8g, Alisma 3g, Citrus aurantii 2g, Cimicifuga 10g.

[0037] Preparation method: (a) take Polygonum multiflorum multiflorum, peach kernel, jujube, Yu Liren, Alisma, Citrus aurantium, Cimicifuga according to the selected parts by weight, add purified water to decoct twice, each time for 2 hours, combine the decoction, and use Filtrate with 200 mesh silk cloth, filter the filtrate with a ceramic microfiltration membrane, the filtration pressure difference is 0.18MPa, the membrane surface flow rate is 6000L / hour, and the filtrate is used as the microfiltrate;

[0038] (b) Concentrate the microfiltrate under reduced pressure to a thick paste with a relative density of 1.20 (80° C.), and let it cool. Add an appropriate amount of sodium carboxymethylcellulose, mix with the thick paste, add 0.8% sucralose, granulate, and dry to obtain the product.

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PUM

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Abstract

The present invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition of improved Jichuan decoction and its preparation method and use. Jujube 2‑10 parts, Yu Liren 2‑10 parts, Alisma 2‑10 parts, Citrus aurantium 2‑10 parts, Cimicifuga 2‑10 parts, all medicines are used together to nourish the kidney and liver, promote blood circulation and remove blood stasis, and nourish blood The effect of moistening the intestines and laxative. It has obvious curative effect on intractable constipation. After 2 courses of treatment, the total effective rate can reach 97.2%. It can obviously relieve clinical symptoms, and has less medicinal taste, quick effect, no adverse reaction, and low recurrence rate.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition of improved Jichuan decoction, a preparation method and application thereof. Background technique [0002] Constipation is a common clinical symptom, manifested as dry stool, difficulty in defecation, and decreased stool weight and frequency. With the aging of society, changes in modern life rhythm and eating habits, and changes in disease spectrum, constipation has become one of the important factors affecting the quality of life of modern people, and it is closely related to the incidence of colorectal cancer. Constipation can be caused by many reasons such as neurogenic, systemic diseases, etc., which is called secondary constipation. If there is no organic disease causing constipation, it is called functional constipation. In the past, it was considered as simple constipation, habitual constipation or idiopathic constipat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/884A61P1/10
CPCA61K36/704A61K36/71A61K36/725A61K36/736A61K36/752A61K36/884A61K2236/331A61K2236/333A61K2236/53A61P1/10A61K2300/00
Inventor 罗雪峰管悦琴刘亚东
Owner 九华华源药业股份有限公司
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