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High cohesion double crosslinking artificial glass body and preparation method thereof

A double cross-linking and vitreous technology, applied in the field of medical materials, can solve the problems of not paying attention to the cohesion of hydrogels, achieve good cohesion and adhesion, good biocompatibility, and reduce the pain of patients

Active Publication Date: 2020-01-07
JIANGSU DISSUETECH MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this technical solution does not pay attention to the cohesion of the hydrogel, which is not the same as the present invention

Method used

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  • High cohesion double crosslinking artificial glass body and preparation method thereof
  • High cohesion double crosslinking artificial glass body and preparation method thereof
  • High cohesion double crosslinking artificial glass body and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Embodiment 1, high cohesion double cross-linked artificial vitreous body complete set of raw materials

[0056] The complete set of high cohesion double cross-linked artificial vitreous body raw materials in this embodiment is composed of a first component and a second component, the first component is aldylated hyaluronic acid, and the second component is aminated hyaluronic acid; The ring-opening rate of the formylated hyaluronic acid is 10-20%, and the grafting rate of the aminated hyaluronic acid is 40-80%. Note: In the preparation method of each component, the ring-opening rate of aldylated hyaluronic acid can be controlled to 10-20%, and the grafting rate of aminated hyaluronic acid can be controlled by controlling the ratio of materials and reaction time. 40-80%.

[0057] The first component of this embodiment is made by following method:

[0058] F1. Dissolve hyaluronic acid in purified water to form a 5-100 mg / mL hyaluronic acid solution (in this embodiment: ...

Embodiment 2

[0075] Embodiment 2, high cohesion double cross-linked artificial vitreous body

[0076] The high cohesive double crosslinked artificial vitreous body of this embodiment is prepared from the complete set of raw materials for the high cohesive double crosslinked artificial vitreous body in Example 1 through the following steps:

[0077] H1. Dissolve the first component in physiological saline containing phosphorus hydrochloric acid to form the first solution of 5-20 mg / mL, and dissolve the second component in physiological saline containing phosphorus hydrochloric acid to form a solution of 5-20 mg / mL Second solution; the concentration of the first component in the first solution is the same as the concentration of the second component in the second solution. In the physiological saline containing phosphorous hydrochloric acid, the concentration range of phosphate is 0.01-0.1M (0.05M is used in this embodiment).

[0078] Note: In actual use, after step H1, pass each solution t...

Embodiment 3

[0086] Embodiment 3, swelling degree measurement experiment

[0087] This embodiment is used to detect the swelling degree of the artificial vitreous body obtained in Example 3 of Example 2.

[0088]The sample of Example 3 of Example 2 was placed in PBS solution after in-situ cross-linking to measure the swelling degree, the weight of the gel was 0.10 g, and the PBS was 10 mL. Take out the sample when it is immersed in PBS for 1, 2, 3, 4, 5, 6, and 24 hours, absorb excess water with filter paper, weigh it, and calculate the swelling rate. Swelling rate=(sample weight at a specific time-sample original weight) / sample original weight×100%, the result is as attached figure 1 shown. It can be seen from the figure that the product swells completely within 6 hours, and does not change after that, and the swelling degree is only 40%, which is far lower than the swelling degree of ordinary gels by hundreds or even thousands.

[0089] It should be noted that the degree of swelling o...

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Abstract

The invention relates to a high cohesion double crosslinking artificial glass body and a preparation method thereof. A hydrogel is prepared from a first solution and a second solution. A first component contained in the first solution is aldehyde hyaluronic acid, and a second component contained in the second solution is aminated hyaluronic acid. The preparation method comprises the step of blending the first solution and the second solution. The high cohesion double crosslinking artificial glass body can be gelled in situ in an empty glass body cavity by injection to effectively jack and press retinas, has no toxic side effects, good biocompatibility and cohesion, cannot cause an intraocular inflammatory reaction and the rising of intraocular pressure, does not need to be taken out twice,and degrades slowly in eyes, and the spare position is replaced and supplemented by aqueous humors; and in addition, the retinas of local detachment are restored through adhesive attraction.

Description

technical field [0001] The invention relates to a high-cohesion double-crosslinked artificial vitreous body and a preparation method thereof, belonging to the technical field of medical materials. Background technique [0002] As far as the applicant knows, the vitreous is the largest tissue in the eye, located between the lens and the retina, and is a gel-like structure made of collagen and sodium hyaluronate. The vitreous body, the lens, the aqueous humor, and the cornea together constitute the refractive system of the eye and support the retina. Clinically, vitrectomy is required for reasons such as vitreous hemorrhage, foreign body in the eyeball, retinal detachment, endophthalmitis, trauma causing the lens to fall into the vitreous cavity or parasites on the retina. into gas or silicone oil. However, the fast absorption of gas cannot provide enough pressure time, and silicone oil can easily cause side effects such as emulsification, increased intraocular pressure, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/26A61L27/50A61L27/58C08B37/08
CPCA61L27/26A61L27/50A61L27/58A61L2400/06A61L2430/16C08B37/0072C08L5/08
Inventor 吴亮亮曹彬万文倩朱健
Owner JIANGSU DISSUETECH MEDICAL TECH CO LTD
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