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Application of D-mannose to preparation of antidepressants

An antidepressant, mannose technology, applied in the field of depression prevention and treatment of D-mannose, depression prevention and treatment

Active Publication Date: 2020-01-21
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] However, the effect of D-mannose on neurological diseases, such as depression, has not been reported yet.

Method used

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  • Application of D-mannose to preparation of antidepressants
  • Application of D-mannose to preparation of antidepressants
  • Application of D-mannose to preparation of antidepressants

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1: Construction of mouse depression model

[0037] After concentration optimization, the wild-type C57BL / 6 (Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.) mice were fed with normal drinking water and D-mannose, and divided into non-stress group and stress group, and the normal drinking water group served as Control: The mice in the non-stress group were petted for 2 minutes every day, fasted for 2 hours (9:00-11:00) and then put back into the original mouse cage for feeding; the mice in the stress group were placed in a fixed mouse cage. Each fixator can be adjusted to limit the movement of the mouse's head and limbs. The holder is transparent resin glass, and there are many small holes on the side wall to ensure that the mice can breathe, but cannot eat or drink. The mice were restrained for 2 hours (9:00-11:00) every day. After the restraint was over, the mice were put back into the original cage and restrained for 14 consecutive days.

Embodiment 2

[0038] Embodiment 2: Behavioral detection of mice

[0039] Behavioral tests were performed on the 15th day after two weeks of chronic restraint stress, and the test time was from 9:00 to 15:00. Mice were divided into two groups: non-stressed mice group and stressed mice group. The experiments were carried out in a quiet room with good light, and the mice were put into the test room to adapt to the environment two hours before the experiment.

[0040] (1) Anxiety-related behavioral testing

[0041] a. Open field test: The open field test detects the voluntary movement ability and anxiety-like behavior of mice. The open-field device is a 40cm*40cm, 35cm-high stainless steel cube with a silver-white bottom and four black side walls. During the test, the mice were placed in the center of the open field to move freely for 30 minutes, and the Smart software was used to analyze the activity trajectory of the mice within 30 minutes. The voluntary movement ability of the mice was e...

Embodiment 3

[0049] Embodiment 3: in vitro test results

[0050] The mice in each experimental group were sacrificed and their brains were taken out. The brain tissue was ground and then processed for testing. The levels of various neurotransmitters in the hippocampus, hypothalamus and prefrontal cortex of the mice in each experimental group were detected. The test results are shown in the attached figure 2 , 3, 4 showed that in the mice that did not receive chronic restraint stimulation and those that received chronic restraint stimulation, the level of neurotransmitter changes in the brain tissue of mice taking D-mannose showed a lower level of depression .

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Abstract

The invention discloses antidepressant activity of D-mannose. The D-mannose can be used for preparing antidepressants and health products. Through animal moulding experiments, animal behavior experiments and in-vitro experiment research, it is proved for the first time that the D-mannose can relieve depression-related behaviors, can combat anxiety and can significantly reduce the level of neurotransmitters in the hippocampus, hypothalamus and prefrontal lobe in the brain of mice. Based on the good antidepressant activity of the D-mannose, the corresponding application of the D-mannose to the preparation of the antidepressants and the health products is correspondingly protected, and a pharmaceutical composition with an antidepressant effect, an antidepressant and an antidepressant health product are provided.

Description

technical field [0001] The invention relates to the field of prevention and treatment of depression, in particular to the application of D-mannose in the field of prevention and treatment of depression. Background technique [0002] Major depressive disorder (Major depressive disorder MDD), as a psychological and neuroimmune disorder, is one of the most important diseases that endanger human physical and mental health. About 350 million people suffer from it every year in the world, and its incidence is still increasing year by year. rising. According to the prediction of the United Nations Health Organization, depression will become the second largest type of disease after cardiovascular disease causing human disability and death in 2020. Its pathogenesis is complex and related to multiple factors including heredity, personality and social environment. Although the exact pathogenesis of depression is still unclear, it has been found that depression caused by different rea...

Claims

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Application Information

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IPC IPC(8): A61K31/7004A61P25/24
CPCA61K31/7004A61P25/24
Inventor 张利宁李艳李媛王群朱法良郭春
Owner SHANDONG UNIV
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