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Application of BACE2 as glioma prognosis/diagnosis/treatment marker

A glioma and marker technology, which is applied in the application field of BACE2 as a glioma prognosis/diagnosis/treatment marker, can solve the problem that the potential mechanism of clinical significance has not been studied, and achieve good reference significance, accuracy and completeness. Study the mechanism, the effect of promoting invasion

Active Publication Date: 2020-02-04
SHANDONG UNIV QILU HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there are few studies on the relationship between BACE2 and glioma in this field, and there are no relevant studies on the expression pattern of BACE2 and glioma, the clinical significance of BACE2 in human glioma, and the potential mechanism of BACE2 function.

Method used

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  • Application of BACE2 as glioma prognosis/diagnosis/treatment marker
  • Application of BACE2 as glioma prognosis/diagnosis/treatment marker
  • Application of BACE2 as glioma prognosis/diagnosis/treatment marker

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0104] 1. Materials and Methods

[0105] 1.1 Clinical samples and databases

[0106] Twenty-nine pairs of glioma tissues (WHOII-IV) were collected from patients undergoing neurosurgery at Qilu Hospital of Shandong University. Subsequently, the tissue was embedded in paraffin. Normal brain tissue samples (n=4) were collected from trauma patients undergoing decompressive therapy for traumatic brain injury. All participants agreed and signed an informed consent form regarding tissue donation for research purposes. Experimental procedures were carried out in accordance with the Declaration of Helsinki. All patients obtained written informed consent. This study was approved by the Neurosurgery Ethics Committee of Qilu Hospital of Shandong University. Additionally, the transcript abundance of BACE2 was analyzed from The Cancer Genome Atlas Research Network (TCGA; n=667; http: / / cancergenome.nih.gov) as well as four external glioma databases (CGGA, GSE16011, GSE4290, and GSE4271)...

Embodiment 2

[0158] 2.1 High expression level of BACE2 is associated with higher grade human glioma.

[0159] To determine the role of BACE2 in the development of glioma, the expression level of BACE2 was analyzed in normal brain tissue, low-grade glioma (LGG) tissue and GBM tissue. Compared with LGG and normal brain tissues, BACE2 mRNA expression was significantly upregulated in GBM tissues in TCGA and CGGA databases ( figure 1 A).

[0160] Based on cancer gene expression profiles, gliomas are classified into four molecular subtypes: neuronal, preneuronal, classical, and mesenchymal. The mesenchymal subtype was associated with poorer clinical outcomes of patients compared with the mesenchymal subtype. Therefore, based on molecular subtypes, the present example detects BACE2 mRNA expression. BACE2 expression levels were significantly increased in the mesenchymal subtype compared to the proneural subtype in the TCGA and CGGA databases ( figure 1 B). In addition, the ROC curve showed th...

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Abstract

The invention belongs to the technical field of glioma prognosis markers, and particularly relates to application of BACE2 as a glioma prognosis / treatment marker. According to the invention, the research results prove that high-level BACE2 expression is related to the high-level human brain glioma, the mesenchymal molecule subtype of GBM and the poor prognosis for the first time; furthermore, TGF[beta] 1 stimulates BACE2 expression by means of Smad dependent signal transduction, so as to regulate the activity of TNF-[alpha] induced NF-[kappa] B by means of a PP1 / IKK pathway to promote tumorigenesis in glioma cells. The BACE2 can be used as a novel biomarker and a potential treatment target for treating human brain glioma.

Description

technical field [0001] The disclosure belongs to the technical field of glioma prognostic markers, and specifically relates to the application of BACE2 as a glioma prognosis / diagnosis / treatment marker. Background technique [0002] The information disclosed in this Background section is only intended to increase the understanding of the general background of the disclosure, and is not necessarily to be taken as an acknowledgment or any form of suggestion that the information constitutes prior art that is already known to those skilled in the art. [0003] According to reports, human glioma is the most common type of primary intracranial tumor, accounting for about 80% of all malignant brain tumors. According to the World Health Organization (WHO), gliomas can be divided into four grades (I-IV) based on histological features, with grade IV tumors or glioblastoma multiforme (GBM) being associated with the worst prognosis, with a median The survival time is only 12-15 months a...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886G01N33/573G01N33/574A61K45/00A61P35/00
CPCA61K45/00A61P35/00C12Q1/6886C12Q2600/118C12Q2600/158G01N33/573G01N33/57407G01N33/57484G01N2333/96472
Inventor 李刚薛皓王会志陈子航邓林赵荣荣薛付忠杨帆许野平张传锋
Owner SHANDONG UNIV QILU HOSPITAL
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