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A kind of preparation process of shot-dried granules

A preparation process and dry granule technology, which is applied in the field of Shegan granule preparation process, can solve the problems of lack of safety, effectiveness and quality stability, inability to form a systematic traditional Chinese medicine granule preparation process, and low precision.

Active Publication Date: 2022-01-07
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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AI Technical Summary

Problems solved by technology

This kind of formula often has the problem of low precision, and cannot form a systematic Chinese medicine granule preparation process, lacking safety, effectiveness and quality stability

Method used

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  • A kind of preparation process of shot-dried granules
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  • A kind of preparation process of shot-dried granules

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Embodiment Construction

[0063] 1. Extraction process route screening research

[0064]Serum Using Chinese medicinal chemistry mode selected six kinds of the active ingredient, comprising baicalin, baicalein, wogonin, tectorum, wild times tectorigenin and ephedrine. In the extraction process route screening, select baicalin, baicalein, wogonin, extraction amount tectorum, Ci wild tectorigenin and ephedrine six kinds of components as an evaluation index of the four processes: (1) Fractionation alcohol precipitation process, (2) non-fractionated alcohol precipitation, (3) co-extraction alcohol precipitation, (4) put together to inspect without alcohol precipitation, extraction to determine a more scientific and rational process route.

[0065] 1.1 Analysis active ingredient

[0066] Baicalin, tectorum, wild times tectorigenin, ephedrine hydrochloride, measured baicalein, wogonin Content Method:

[0067] Chromatographic conditions: acetonitrile as mobile phase A, 0.1% phosphoric acid as mobile phase B, the f...

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Abstract

The invention provides a preparation process of Shegan granule, which includes one main drug and at least two auxiliary drugs, and is characterized in that it includes: S1 extraction process route screening process, S2 main drug extraction process condition screening process and S3 auxiliary drug extraction process condition Screening process; this process adopts modern Chinese medicine production and analysis and detection technology, conducts scientific and systematic research on the extraction, preparation, and pilot test of this variety, and develops it into a modern medicine that is safe, effective, stable in quality, and easy to use. Chinese medicine preparations.

Description

Technical field [0001] The present invention relates to the field of traditional Chinese medicine preparations, and Background technique [0002] Existing Chinese medicine preparations are often formulated under the guidance of experience or traditional prescription. Such formulation schemes often have problems with high precision and unable to form a systematic Chinese medicine particle preparation process, lack of safety and effectiveness and quality stability. Inventive content [0003] The present invention aims to overcome the above defects, under the guidance of the theory of Chinese medicine, in accordance with the requirements of the National Drug Registration Management Measures, the pre-clinical study of Chinese medicine is carried out. It uses modern Chinese medicine production and analysis testing technology to extract, preparations, and medium-sized research, the research is developed into a modern Chinese medicine preparation developed into a safe and effective, st...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K36/88A61K36/736A61K35/64A61K36/539A61K36/23A61K36/31A61K36/904G01N30/02G01N33/15
CPCA61K36/88A61K36/736A61K35/64A61K36/539A61K36/23A61K36/31A61K36/904A61K9/1652G01N30/02G01N33/15A61K2236/53A61K2236/331A61K2236/39A61K2300/00
Inventor 张健樊敏伟姚譞徐阿晶祁佳马婧张春黄晓会张其锵叶青
Owner XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE