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Use of epi-vogeloside for treating myocardial ischemia reperfusion injury

A technology of reperfusion injury and loganin, which is applied in the field of medicine

Active Publication Date: 2020-02-07
BEIJING RONGXIANG INST OF REGENERATIVE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Preliminary tests found that broken loganin hemiacetal lactone does not have the effect of anti-myocardial ischemia-reperfusion injury, but because the chemical structure and three-dimensional conformation of broken strychnin hemiacetal lactone are different from broken strychnolactone Therefore, whether loganin hemiacetal lactone has anti-myocardial ischemia-reperfusion injury is still unknown

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  • Use of epi-vogeloside for treating myocardial ischemia reperfusion injury
  • Use of epi-vogeloside for treating myocardial ischemia reperfusion injury
  • Use of epi-vogeloside for treating myocardial ischemia reperfusion injury

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Embodiment Construction

[0018] The substantive content of the present invention will be described in detail below in conjunction with the accompanying drawings, but those skilled in the art should know that the protection scope of the present invention is not limited by the following content.

[0019] 1. Materials and methods

[0020] 1. Animal grouping, modeling and administration

[0021] 40 adult male SD rats (body weight 260-300g) were randomly divided into sham operation group, myocardial ischemia-reperfusion model group, epiloganin hemiacetal lactone group and loganin hemiacetal lactone group and loganin hemiacetal lactone group. Acetal lactone group, 10 rats in each group. Myocardial ischemia-reperfusion model was produced by ligation of the left anterior descending coronary artery commonly used in the field, and the specific operations were as follows:

[0022] Rats were anesthetized with 3% pentobarbital sodium, fixed, and electrodes were inserted subcutaneously in the limbs to monitor lea...

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Abstract

The invention discloses a use of epi-vogeloside for treating myocardial ischemia reperfusion injury. The experimental results show that epi-vogeloside pretreatment can effectively reduce myocardial ischemia reperfusion injury in rats, and the mechanism of action of the epi-vogeloside pretreatment is related to reducing myocardial cell apoptosis in ischemia reperfusion rats, and the epi-vogelosidecan be used for preparing medicine for antagonizing myocardial ischemia reperfusion injury. The activity of epi-vogeloside is related to the chemical structure and stereo configuration.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the medical use of epiloganin hemiacetal lactone, in particular to the use of epiloganin hemiacetal lactone for treating myocardial ischemia-reperfusion injury. Background technique [0002] As a complex physiological and pathological process, myocardial ischemia-reperfusion injury has always been the focus of attention in the cardiovascular field. In recent years, it has been reported in the literature that when myocardial ischemia-reperfusion injury occurs, the way of drug pretreatment can protect the myocardial tissue of ischemia-reperfusion, which may be related to the drug activation of the body's endogenous protective mechanism or the release of endogenous protective mediators. . [0003] Epi-broken loganin hemiacetal lactone and broken loganin hemiacetal lactone are a pair of chiral compounds with the following structural formula. [0004] [0005] Preliminary tests found that b...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P9/10
CPCA61K31/7048A61P9/10
Inventor 吴海靖其他发明人请求不公开姓名
Owner BEIJING RONGXIANG INST OF REGENERATIVE MEDICINE
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