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Novel use of penthorum chinense pursh in prevention and treatment of renal albuminuria

A technology for catching yellow grass and proteinuria is applied in the field of new application of catching yellow grass in preventing and treating renal proteinuria, and can solve the problems such as no research report of catching yellow grass on renal proteinuria.

Inactive Publication Date: 2020-02-07
SOUTHWEST MEDICAL UNIVERISTY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no research report on the prevention and treatment of renal proteinuria by Ganhuangcao

Method used

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  • Novel use of penthorum chinense pursh in prevention and treatment of renal albuminuria
  • Novel use of penthorum chinense pursh in prevention and treatment of renal albuminuria

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 The effect of the extract of C. chinensis on proteinuria in nephrotic syndrome

[0020] Fifty male healthy SD rats with a body weight of (200±20) g were taken, and after one week of adaptive feeding with free diet, they were randomly divided into a normal control group (Group A) of 10 rats and a model group of 40 rats. The model group was randomly divided into 4 groups, namely the model control group (group B), the positive control group (group C), the high-dose group of C. ), 10 in each group. The model group was injected with doxorubicin (5.5 mg·kg -1 ) to establish the doxorubicin nephrotic syndrome rat model; the rats in group A were injected with the same amount of normal saline through the tail vein according to the above method. After the successful modeling, the rats in each group were given intragastric administration from the 21st day after the modeling, once a day. Among them, groups A and B received ig the same amount of normal saline, and group...

Embodiment 2

[0025] Example 2 The effect of total flavonoids of C. chinensis on proteinuria in rats with nephrotic syndrome

[0026] Fifty male healthy SD rats with a body weight of (250±20) g were taken, and after one week of adaptive feeding with free diet, they were randomly divided into a normal control group (Group A) of 10 rats and a model group of 40 rats. The model group was randomly divided into 4 groups, namely the model control group (group B), the positive control group (group C), the high-dose total flavonoids group (group D), and the low-dose total flavonoids group (group E). ), 10 in each group. Rats in the model group were injected (iv) 4 mg·kg into the tail vein on the 1st and 8th day of modeling respectively -1 and 1mg·kg -1 Doxorubicin; Normal rats were given the same volume of normal saline iv. The 24-h urine was collected once every 1 week, and the 24-h urine protein content of rats in each group was detected by the biuret protein concentration method. When the 24-h...

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Abstract

The invention aims to provide a novel use of penthorum chinense pursh and medicine or health care food prepared from the penthorum chinense pursh, and particularly relates to the novel use of the penthorum chinense pursh and the medicine or health care food prepared from the penthorum chinense pursh in the prevention and treatment of renal albuminuria. Tests show that the penthorum chinense purshhas an effect of reducing urinary proteins of nephropathy. According to the novel use, the application scope of the penthorum chinense pursh is enlarged, and a basis is provided for the clinical application of the penthorum chinense pursh in the prevention and treatment of the renal albuminuria.

Description

[0001] 1. Technical field [0002] The invention relates to a new application of C. chinensis, in particular to a new application of C. sativa in preventing and treating renal proteinuria, and belongs to the field of traditional Chinese medicines. [0003] 2. Background technology [0004] Huangcao is the dry above-ground part of Penthorum chinense pursh., a plant of the genus Penthorum chinense pursh. in the family Saxifragaceae. It is a dual-purpose plant for medicine and food among the Miao people. It is mainly produced in Sichuan, Guizhou, Hunan and other places. Herba Rhizome is flat in nature, bitter in the mouth, slightly pungent, nontoxic, and returns to the Liver and Kidney meridians. It has the effects of clearing away heat and detoxification, reducing jaundice and removing dampness, promoting blood circulation and dissipating blood stasis, diuresis and detumescence, and mainly treats jaundice, amenorrhea, edema, traumatic injuries, etc. C. chinensis belongs to the L...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P13/12A23L33/10A23L33/105A23F3/34
CPCA23F3/34A23V2002/00A61K36/00A61K36/185A23L33/10A23L33/105A61P13/12A61K2300/00A23V2200/30A23V2250/21A23V2250/2116
Inventor 袁叶飞白雪
Owner SOUTHWEST MEDICAL UNIVERISTY
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