Composition containing phenyl-carbamoyl thiazole derivative mixture and application of composition
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A technology of phenylcarbamoyl thiazole and composition is applied in the directions of medical preparations containing active ingredients, plant raw materials, organic active ingredients, etc., and can solve problems such as further improvement.
Inactive Publication Date: 2020-02-11
黄泳华
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[0005] Plant extracts are rich in a variety of ingredients with antibacterial activity. For example, Yang Ruoying et al. reported (Journal of Tropical Biology, 2019, 10(03): 226-230.) The extracts of plants such as horn wind, six ear bells, rattan notoginseng, Guanzhong, golden thread grass, unipedal wind, eight hundred centimeters, and piercing stone have the effect on tobacco Ralstonia solanacearum at 100mg / L and / or 500mg / L Certain antibacterial activity, but the inventors found that the antibacterial activity of the above-mentioned plant extracts to other common pathogenic bacteria needs to be further improved
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preparation example 1
[0023] The preparation of preparation example 1 plant extract
[0024] Ultrasonic extraction method is used to dry the shade-dried plant material at 40°C, crush it, pass through a 40-mesh sieve, and put it into a ziplock bag. Before the test, 50 g of plant dry powder was weighed, and different organic solvents were added for ultrasonic extraction (as shown in Table 1), and the extraction was repeated 3 times for 60 min each time. Concentrate after filtration and store in a refrigerator at 4°C until use.
[0025] Table 1 Organic solvents for ultrasonic extraction of different plant extracts
[0026]
[0027]
Embodiment 1
[0102] Embodiment 1 Preparation of oral solid preparation of a composition containing a mixture of phenylcarbamoylthiazole derivatives
[0103] Prescription (1500 unit dose)
[0104]
[0105]
[0106] Preparation
[0107] Take the prescribed amount of MIX (X-Y-PEZ) and auxiliary materials, and pass through a 100-mesh sieve. Take MIX (X-Y-PEZ), lactose, microcrystalline cellulose, crospovidone and starch and mix thoroughly; take the prescribed amount of hypromellose, and prepare it into a product with a concentration of 10% based on hypromellose Solution, adjust the pH to 3.0-4.0 with lactic acid, add to the above-mentioned mixed material to make a soft material, granulate with a 16-mesh sieve, and dry at 80°C for 3-4 hours. Use a 16-mesh sieve to sieve the granules, add the prescribed amount of micropowder silica gel and magnesium stearate, mix well, fill the capsules, and obtain capsules;
[0108] Take the prescribed amount of MIX (X-Y-PEZ) and auxiliary materials, ...
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Abstract
The invention provides a composition containing a mixture of a first phenyl-carbamoyl thiazole derivative and a second phenyl-carbamoyl thiazole derivative which are different from each other. Together with extracts of plants such as crotalaria assamica, star anise fruits, calophyllum membranaceum, schisandrae virides caulis, cycas leaves and the like, the mixture can generate synergistic antibacterial action on staphylococcus hominis, pantoea agglomerans, kocuria kristinae, serratia liquefaciens, ralstonia pickettii, peptostreptococcus anaerobius, klebsiella oxytoca, corynebacterium macginleyi, listeria monocytogens, simulation corynebacterium, clostridium perfringens, staphylococcus haemolyticus, aeromonas hydrophila, acinetobacter baumannii, streptococcus sanguis, peptostreptococcus prevotii, propionibacterium acnes, pseudomonas oryzihabitans, staphylococcus warneri, and legionella pneumophila.
Description
technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a composition containing a mixture of phenylcarbamoylthiazole derivatives and its application. Background technique [0002] Nosocomial infection is an important issue affecting the quality of hospital care. With the continuous development and progress of modern medical technology, antibacterial drugs are widely used, and the drug-resistant strains of clinical pathogens are increasing. Therefore, improving the antibacterial activity of existing drugs will help to improve the therapeutic effect of patients with bacterial infections. [0003] CN108939081A discloses a variety of protein tyrosine kinase inhibitors with antibacterial activity, including phenylcarbamoylthiazole derivatives represented by formula I. [0004] [0005] Plant extracts are rich in a variety of ingredients with antibacterial activity. For example, Yang Ruoying et al. reported (Journal of Tro...
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