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Hydrogel tablets for dispelling effects of alcohol and protecting liver as well as preparation method and application thereof

A technology for hangover protection, liver protection and water coagulation, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve the problems of slow onset of alcohol damage and achieve high gel strength , increase the absorption speed, increase the effect of absorption

Active Publication Date: 2020-02-14
GUANGDONG OCEAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The primary purpose of the present invention is to overcome the shortcomings of the existing anti-alcohol products that have anti-alcohol effects but cannot directly reduce the damage to organs caused by the rapid absorption of ethanol and the slow onset of effect, and provide a composition with anti-alcohol and liver-protecting effects

Method used

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  • Hydrogel tablets for dispelling effects of alcohol and protecting liver as well as preparation method and application thereof
  • Hydrogel tablets for dispelling effects of alcohol and protecting liver as well as preparation method and application thereof
  • Hydrogel tablets for dispelling effects of alcohol and protecting liver as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1 Preparation of a hangover-protecting liver hydrogel tablet

[0044] A hangover-protecting liver hydrogel sheet, which consists of the following components in parts by weight: 30 parts of chitosan, 40 parts of sodium alginate, 11 parts of fish gelatin, 4 parts of calcium carbonate, and 0.2 parts of gallic acid; Fish gelatin is extracted conventionally from offals of tilapia, cod or tuna.

[0045] The preparation method of the hydrogel sheet described in the present embodiment comprises the following steps:

[0046] S1. according to the above-mentioned parts by weight, get chitosan and add in the acidic solution to be mixed with 1.5% chitosan solution, adjust the solution to be pH 5.8, add the calcium carbonate powder and 1% sodium alginate solution successively to which the particle diameter is 1800 , vortex vibration treatment for 15 minutes, freeze-drying to obtain chitosan / sodium alginate (shell)-calcium carbonate (core) powder;

[0047] S2. Dissolving fis...

Embodiment 2

[0049] Example 2 Preparation of a hangover-protecting liver hydrogel tablet

[0050] A hangover-protecting liver hydrogel sheet, which consists of the following components in parts by weight: 25 parts of chitosan, 30 parts of sodium alginate, 8 parts of fish gelatin, 3 parts of calcium carbonate and 0.1 part of gallic acid. The fish gelatin is extracted from leftovers of tilapia, cod or tuna according to conventional techniques.

[0051] The preparation method of the hydrogel sheet described in the present embodiment comprises the following steps:

[0052] S1. According to the above parts by weight, get chitosan and add it into an acidic solution to prepare a 1% chitosan solution, adjust the solution to be pH 5.5, and add calcium carbonate powder and 0.5% sodium alginate solution successively to which the particle size is 1000 mesh , vortex vibration treatment for 10 minutes, freeze-drying to obtain chitosan / sodium alginate (shell)-calcium carbonate (core) powder;

[0053] S...

Embodiment 3

[0055] Example 3 Preparation of a hangover-protecting liver hydrogel tablet

[0056] A hangover-protecting liver hydrogel sheet is composed of the following components in parts by weight: 35 parts of chitosan, 50 parts of sodium alginate, 15 parts of fish gelatin, 5 parts of calcium carbonate and 0.3 part of gallic acid. The fish gelatin is extracted from leftovers of tilapia, cod or tuna according to conventional techniques.

[0057] The preparation method of the hydrogel sheet described in the present embodiment comprises the following steps:

[0058] S1. According to the above parts by weight, get chitosan and add it into an acidic solution to prepare a 3% chitosan solution, adjust the solution to be pH 6.0, and add calcium carbonate powder and 1.5% sodium alginate solution successively to which the particle size is 2500 mesh , vortex vibration treatment for 20 minutes, freeze-drying to obtain chitosan / sodium alginate (shell)-calcium carbonate (core) powder;

[0059] S2. ...

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Abstract

The invention discloses hydrogel tablets capable of dispelling effects of alcohol and protecting liver as well as a preparation method and an application thereof. The invention firstly provides a composition with hangover alleviating and liver protecting effects, which is prepared from the following components in parts by weight: 20 to 40 parts of chitosan, 25 to 55 parts of sodium alginate, 3 to20 parts of gelatin, 1 to 10 parts of calcium carbonate and 0.05 to 0.5 part of gallic acid. Based on the composition, the invention also provides the hydrogel tablets for dispelling the effects of alcohol and protecting the liver. According to the invention, chitosan, sodium alginate and calcium carbonate are compounded according to a proper proportion to form chitosan / sodium alginate (shell)-calcium carbonate (core) powder particles, gelatin and gallic acid are added, and after the stomach encounters alcohol, the product can quickly swell, slow down rapid absorption of the alcohol and achieve the effects of dispelling the effects of alcohol and protecting the liver; meanwhile, the composition has the advantages of simple components, quick response, capability of directly slowing down rapid absorption of alcohol and quickly achieving the effects of dispelling the effects of alcohol and protecting the liver, convenience in taking, no unpleasant odor and good compliance.

Description

technical field [0001] The invention belongs to the technical field of biomedicine. More specifically, it relates to a hangover-protecting liver hydrogel sheet and its preparation method and application. Background technique [0002] The number of deaths due to alcoholism is about 2.5 million in the world every year, accounting for 4% of the total number of deaths. Alcohol abuse, especially among young people, has become a major public health problem in the whole society. In China, liver damage caused by alcohol has become the second largest cause after viral hepatitis and is increasing year by year. Throughout the ages, wine culture has played a certain positive role in politics, economy and social life. Alcohol has become an indispensable entertainment in social occasions, and the phenomenon of drunkenness is inevitable. "Drinking too much hurts the body, but drinking a little to make you happy." Moderate drinking has the effects of promoting blood circulation, dredgin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/10A61K9/20A61K31/722A61K31/734A61K47/36A61K47/42A61K47/12A61P1/16A61P39/00
CPCA61K31/722A61K31/734A61K33/10A61K9/205A61K9/2063A61K9/2013A61P1/16A61P39/00A61K2300/00A61K9/1652A61K9/2072A61K9/2095A61K9/2009
Inventor 胡章卢思彤孔松芝李思东张岭誉廖铭能李程鹏程瑜
Owner GUANGDONG OCEAN UNIVERSITY
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