Nanometer tinidazole carbon point as well as preparation method and application thereof
A technology of nitrazole carbon dots and nitrazole carbons is applied in the field of medicine, which can solve the problems of inability to destroy the drug resistance of Gram-negative anaerobic bacteria, large size of drugs, high drug resistance, etc., so as to avoid bacterial drug resistance. Increased sexuality, shorter time-consuming, less side effects
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Embodiment 1
[0034] A preparation method of nano tinidazole carbon dots, comprising the following steps:
[0035] Weigh 3mmol of pure tinidazole and grind it fully with agate grinder, then dissolve it in 10mL ultrapure water, stir thoroughly for 10min, transfer the solution to a 100mL Teflon-lined autoclave, seal it and store it at 180°C, Heat the reaction at high temperature for 8 hours; then, wait for the reactor to cool down to room temperature naturally, filter the crude reaction product through a 0.22 μm polyethersulfone membrane to remove unreacted agglomerated particles, collect the liquid and dialyze it against ultrapure water for 20 hours in an 800Da dialysis bag; Finally, the dialyzed liquid was freeze-dried overnight to prepare nano-tinidazole carbon dots for further characterization.
Embodiment 2
[0037] A preparation method of nano tinidazole carbon dots, comprising the following steps:
[0038] Weigh 5mmol of pure tinidazole and grind it thoroughly with agate, then dissolve it in 20mL of ultrapure water, stir thoroughly for 50min, transfer the solution to a 100mL Teflon-lined autoclave, seal it and store it at 250°C, Heat the reaction at high temperature for 12 hours, then wait for the reactor to cool down to room temperature naturally, filter the crude reaction product through a 0.22 μm polyethersulfone membrane to remove unreacted agglomerated particles, collect the liquid and dialyze it against ultrapure water for 48 hours in an 800Da dialysis bag, Finally, the dialyzed liquid was freeze-dried overnight to prepare nano-tinidazole carbon dots.
Embodiment 3
[0040] A preparation method of nano tinidazole carbon dots, comprising the following steps:
[0041]Weigh 3mmol of pure tinidazole and grind it thoroughly with agate, then dissolve it in 30mL of ultrapure water, stir thoroughly for 20min, transfer the solution to a 100mL Teflon-lined autoclave, seal it and store it at 200°C, Heat the reaction at high temperature for 24 hours, then wait for the reactor to cool down to room temperature naturally, filter the crude reaction product through a 0.22 μm polyethersulfone membrane to remove unreacted agglomerated particles, collect the liquid and dialyze it against ultrapure water in an 800Da dialysis bag for 12 hours, Finally, the dialyzed liquid was freeze-dried overnight to prepare nano-tinidazole carbon dots.
[0042] The properties of the nano-tinidazole carbon dots prepared in the above-mentioned Examples 1 to 3 are similar, and the nano-tinidazole carbon dots prepared in Example 1 are used as an example below to illustrate its pe...
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