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Method for constructing chitosan-PMCP/gelatin coating on surface of bionic porous titanium alloy

A technology of phosphocholine and chitosan, which is applied in the field of medical devices, can solve problems such as compounding, and achieve the effects of promoting non-specific protein adsorption, enhancing cell adhesion and anti-non-specific protein adsorption

Active Publication Date: 2020-02-14
中国人民解放军西部战区总医院
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  • Abstract
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Problems solved by technology

However, how to compound PMCP molecules with strong cell adhesion effect to the porous titanium alloy surface is the bottleneck of this idea.

Method used

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Experimental program
Comparison scheme
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Embodiment Construction

[0027] The preparation method of the present invention is as follows:

[0028] 1) Prepare phosphoric acid choline monomer, and modify chitosan with phosphoric acid polycholine

[0029] Take 5mL of solvent tetrahydrofuran at -20°C, add 8mmol of acid-binding agent triethylamine, 8mmol of methanol and 8mmol of 2-chloro-2-oxo-1,3,2-dioxaphospholane to it, and then use decompression The obtained intermediate product 2-methoxy-2-oxo-1,3,2-dioxaphospholane obtained by suction filtration, and 8 mmol of the intermediate product 2-methoxy-2-oxo-1,3,2- Add 10 mL of dimethylaminoethyl methacrylate and 10 mL of acetonitrile to 2-methoxy-2-oxo-1,3,2-dioxaphospholane for ring-opening reaction , after the reaction is finished, monomer phosphoric acid choline is obtained by precipitating with tetrahydrofuran solution as a precipitating agent;

[0030] Chitosan with a deacetylation degree greater than 95%: 2-bromoisobutyryl bromide is mixed in a molar ratio of 1:2 to obtain chitosan-Br, and t...

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Abstract

The invention discloses a method for constructing a chitosan-PMCP / gelatin coating on the surface of bionic porous titanium alloy. The method comprises the steps as follows: firstly, preparing CP (choline phosphate) monomers, and modifying chitosan with PMCP; then, preparing an electrophoretic solution, and putting the electrophoretic solution into an electrophoresis container for electrophoretic deposition to obtain the porous titanium alloy with the chitosan-PMCP / gelatin coating. The porous titanium alloy with the chitosan-PMCP / gelatin coating prepared by the method has the functions of restraining non-specific protein adsorption and promoting cell adhesion; compared with single-layer CP, the PMCP is further enhanced in hydrophily, cell adhesion and resistance to non-specific protein adsorption.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a method for constructing a chitosan-polycholine phosphoric acid / gelatin coating on the surface of a bionic porous titanium alloy. Background technique [0002] The repair of large bone defects has always been a difficult problem in the fields of trauma orthopedics and bone tumors. In recent years, with the rapid development of 3D printing, the rapid prototyping technology of electron beam melting and selective laser melting can effectively prepare porous titanium alloys with complex external configuration and internal microporous structure, which greatly simplifies the preparation of previous porous titanium alloys. The technique reduces the cost, and provides a new method and reference for solving the problem of repairing large bone defects. [0003] However, titanium alloy is a biologically inert metal and lacks biological activity. After a large segment of porous t...

Claims

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Application Information

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IPC IPC(8): C25D13/06C25D13/22A61L27/34A61L27/06A61L27/56C08B37/08
CPCA61L27/06A61L27/34A61L27/56A61L2420/02A61L2420/06A61L2430/02C08B37/003C25D13/04C25D13/22C08L85/02C08L89/00
Inventor 王财儒陈星羽郑伟谢庆云卢敏
Owner 中国人民解放军西部战区总医院
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