Marker for early diagnosis of diabetes mellitus and kit thereof, and application of marker for early diagnosis of diabetes mellitus

An early diagnosis and marker technology, applied in the field of diabetes diagnosis, can solve problems such as poor stability, susceptible to environmental factors, unpredictable or early prompting of diabetes, etc., to prevent misdiagnosis and missed diagnosis, and achieve the effect of strong stability

Pending Publication Date: 2020-02-21
YIXING PEOPLES HOSPITAL
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  • Abstract
  • Description
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Problems solved by technology

[0004] The traditional method has clear significance for the diagnosis of T2DM, but it cannot predict or prompt the occurrence of diabetes as early as possible, which is not very helpful for the prevention and treatment of the disease
The newly proposed method in the prior art uses DNA or non-coding RNA in serum as a detection target for early diagnosis of diabetes, which is easily affected by environmental factors, has poor stability and poor detection effect
[0005] Currently available diagnostic methods for diabetes are not effective for early prediction or diagnosis of diabetes

Method used

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  • Marker for early diagnosis of diabetes mellitus and kit thereof, and application of marker for early diagnosis of diabetes mellitus
  • Marker for early diagnosis of diabetes mellitus and kit thereof, and application of marker for early diagnosis of diabetes mellitus
  • Marker for early diagnosis of diabetes mellitus and kit thereof, and application of marker for early diagnosis of diabetes mellitus

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Embodiment 1

[0033] test subject

[0034] The test subjects were newly diagnosed T2DM patients and healthy people with similar height, weight, age and gender who were treated in Yixing Hospital Affiliated to Jiangsu University from August 2018 to August 2019.

[0035] The general information of the subjects was collected according to the following criteria: age, body mass index, blood pressure, liver and kidney function, fasting blood glucose level, 2h postprandial blood glucose level, glycosylated hemoglobin level, basic medical history / life history, etc. (see Table 1 for details).

[0036] Inclusion criteria for newly diagnosed T2DM group: fasting venous blood glucose ≥7.0mmol / L; 2h postprandial blood glucose ≥11.0mmol / L; glycosylated hemoglobin: ≥6.5%; age: 18 to 75 years old; gender: not limited.

[0037]Inclusion criteria for the control group: 4.16mmol / L≤fasting venous blood glucose≤6.44mmol / L; 2h postprandial blood glucose≤7.8mmol / L; glycosylated hemoglobin:≤6.5%; levels of gender, ...

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Abstract

The invention provides a marker for early diagnosis of diabetes mellitus and application thereof, and belongs to the technical field of diabetes mellitus diagnosis. The marker for early diagnosis of diabetes mellitus comprises lipid PC(P18:1(9Z) / 16:0) and / or PE(22:2(13Z, 16Z) / 14:0); the expression quantity of the lipid PC(P18:1(9Z) / 16:0) and / or PE(22:2(13Z, 16Z) / 14:0) in the serum exosome of a healthy person is remarkably different from the expression quantity of the lipid PC(P18:1(9Z) / 16:0) and / or PE(22: 2(13Z, 16Z) / 14:0); and therefore, the marker for early diagnosis of diabetes mellitus provided by the invention can be used as a target for early diagnosis of diabetes mellitus; by detecting the content of the marker in the serum exosome, early diagnosis of diabetes mellitus can be effectively carried out, and misdiagnosis and missed diagnosis are prevented.

Description

technical field [0001] The invention belongs to the technical field of diabetes diagnosis, in particular to a marker for early diagnosis of diabetes and its application. Background technique [0002] Diabetes mellitus is a metabolic disease mainly manifested by elevated blood sugar, which can induce a variety of severe acute and chronic complications, of which more than 90% are type 2 diabetes mellitus (T2DM). The onset of T2DM is hidden, and early prevention and treatment are of great significance for controlling the progression of the disease. Traditional blood sugar, glycosylated hemoglobin, and insulin concentration detection methods are of clear significance for the diagnosis of T2DM, but they cannot predict or prompt the occurrence of diabetes as early as possible. How to predict the occurrence of T2DM early and take intervention measures as early as possible is a hot spot for doctors and patients. [0003] Oxidative stress is one of the important mechanisms of diabet...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/92
CPCG01N33/92G01N2800/042
Inventor 孙瑶湘董永康乔国洪毛旭华吴雪琴张燕
Owner YIXING PEOPLES HOSPITAL
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