Compositions and methods for treatment of enterovirus infection

Abstract

Enteroviruses, such as EV-A71, have been found to utilize hWARS as a cell surface receptor, with expression of hWARS rendering cells susceptible to enteroviral infection. Reduction in hWARS cell surface activity reduces susceptibility to enteroviral infection and provides a mode for treatment or prevention of enteroviral infection and its sequelae. Similarly, expression of hWARS in cultured cellsand animal models provides models for understanding enteroviral disease mechanisms and the development of vaccines and / or pharmaceuticals for preventing or treating enteroviral disease.

Description

[0001] This application claims priority to U.S. Provisional Patent Application No. 62 / 394,061, filed September 13, 2016. These and all other referenced extrinsic materials are hereby incorporated by reference in their entirety. Where a definition or use of a term in a reference incorporated by reference is inconsistent or contrary to the definition of that term provided herein, the definition of that term provided herein is considered controlling. technical field [0002] The field of the invention is compositions and methods for the treatment of enterovirus infections, in particular enterovirus 71 . Background technique [0003] The Background Description includes information useful for understanding the present invention. It is not an admission that any of the information presented herein is prior art or relevant to the presently claimed invention, or that any publication specifically or implicitly referenced is prior art. [0004] Enteroviruses are a diverse group of po...

AI Technical Summary

Problems solved by technology

However, their expression patterns do not fully account for many aspects of the disease, including tissue tropism of viral replication and clinical manifestations

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