Apoptosis Signal Regulated Kinase Inhibitor and Application

Abstract

The invention discloses a cell apoptosis signal regulating kinase inhibitor and application thereof. Compounds as shown in general formula I, tautomers thereof or pharmaceutically acceptable salts thereof: the present invention provides a class of compounds with novel structures, and pharmacodynamic experiments prove that the compounds of the present invention have a relatively high effect on ASK1 receptors. Good inhibitory ability, can effectively inhibit the formation of fibrosis in vitro, and has low toxicity to normal cells. Accordingly, the compounds of the present invention are useful in the treatment of a variety of fibrosis and related diseases.

Description

Apoptosis signal-regulated kinase inhibitor and its application technical field [0001] The present invention relates to the field of medicinal chemistry, in particular to apoptosis signal-regulated kinase inhibitors and applications thereof. Background technique Mitogen-activated protein kinase (MAPK) signaling cascades link distinct extracellular and intracellular queues with appropriate cellular A combination of cellular stress responses, including cell growth, differentiation, inflammation, and apoptosis. MAPK is activated in sequence by three components Member MAP3K, MAP2K and MAPK exist. MAPK3 directly responds to environmental signals and phosphorylates MAP2K, which in turn specifically Phosphorylates MAPKs, which in turn mediate proper cellular response. Apoptosis Signal-Regulating Kinase 1 (ASK1) is an activator of c-Jun N-terminal protein kinase (JNK) and p38MAP kinase Mitogen-activated protein kinase kinase kinase (MAP3K) family member. by including ...

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Problems solved by technology

Therefore, when ASK1 is activated, it can lead to the activation of hepatic stellate cells, which leads to the deposition of extracellular matrix, which eventually leads to the occurrence of liver fibrosis

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