S-enantiomers of beta-hydroxybutyrate and butanediol and methods for using same
A technology of enantiomer and hydroxybutyrate, which is applied to the S enantiomer of β-hydroxybutyrate and butanediol and its application field, which can solve problems such as difficulty in long-term persistence
Pending Publication Date: 2020-04-21
THE BUCK INST FOR RES ON AGING +2
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Problems solved by technology
The ketogenic diet is clinically used as a treatment for epilepsy, but it is often difficult to adhere to in the long term
Method used
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Embodiment 1
[0197] Inhibition of HDACs by S-BHB
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In various embodiments a compound comprising the enantiomerically enriched S-isomer S-BHB-S-1,3-butanediol is provided along with methods of use thereof.
Description
[0001] Cross References to Related Applications [0002] This application claims the benefit and priority of USSN 62 / 535,754, filed July 21, 2017, which is hereby incorporated by reference in its entirety for all purposes. [0003] Statement of Government Support [0004] This invention was made with government support under Grant Nos. R24DK085610 and K08AG048354 awarded by the National Institutes of Health. The government has certain rights in this invention. Background technique [0005] The ketogenic diet and ketone bodies can be used to treat a variety of human diseases, including epilepsy, dementia, and diseases of aging. Ketone bodies are small molecular compounds produced by fat that serve as sugar substitutes when the body's energy stores are depleted, such as during fasting or intense exercise. A ketogenic diet stimulates ketone body production by including very little sugar or other carbohydrates. The main ketone bodies in humans are acetoacetate (AcAc) and β-hyd...
Claims
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Patent Timeline
Login to View More IPC IPC(8): A61K31/22C07C69/675
CPCA23L2/00A61K45/06A61K31/22C07C69/675A23L2/38A61K9/0056A61P25/00A61K31/19A61K2300/00A23L29/035A61P25/28C07B2200/07
Inventor E·维丁J·C·纽曼
Owner THE BUCK INST FOR RES ON AGING
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